Hel** B cells and antibody responses is a major function of CD4+ T cells. It has been 10
years since the publication of Bcl6 as the lineage-defining transcription factor for T follicular …

The immune system and cancer have a complex relationship with the immune system
playing a dual role in tumor development. The effector cells of the immune system can …

Beta2-integrins are complex leukocyte-specific adhesion molecules that are essential for
leukocyte (eg, neutrophil, lymphocyte) trafficking, as well as for other immunological …

β2 integrins are heterodimeric surface receptors composed of a variable α (CD11a-CD11d)
and a constant β (CD18) subunit and are specifically expressed by leukocytes. The α …

B cell zone reticular cells (BRCs) form stable microenvironments that direct efficient humoral
immunity with B cell priming and memory maintenance being orchestrated across lymphoid …

The lymphocyte function-associated antigen-1 (LFA-1)(also known as CD11a/CD18 and
αLβ2), is just one of many integrins in the human body, but its significance is derived from its …

Following stimulation, the T cell receptor (TCR) and its coreceptors integrate multiple
intracellular signals to initiate T cell proliferation, migration, gene expression, and …

The germinal center (GC) reaction begins with a diverse and expanded group of B cell
clones bearing a wide range of antibody affinities. During GC colonization, B cells engage in …

Highlights•Original BCR repertoires affect the fate decisions of B cells.•Plasma cell fate is
facilitated by higher affinity in both pre-GC and GC responses.•High expression of IRF4 is …

The integrin lymphocyte function–associated antigen 1 (LFA-1) helps to coordinate the
migration, adhesion, and activation of T cells through interactions with intercellular adhesion …