Non-viral vectors in gene therapy: recent development, challenges, and prospects
H Zu, D Gao - The AAPS journal, 2021 - Springer
Gene therapy has been experiencing a breakthrough in recent years, targeting various
specific cell groups in numerous therapeutic areas. However, most recent clinical studies …
specific cell groups in numerous therapeutic areas. However, most recent clinical studies …
Polymeric delivery of therapeutic nucleic acids
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …
The endosomal escape of nanoparticles: toward more efficient cellular delivery
SA Smith, LI Selby, APR Johnston… - Bioconjugate …, 2018 - ACS Publications
Many emerging therapies rely on the delivery of biological cargo into the cytosol.
Nanoparticle delivery systems hold great potential to deliver these therapeutics but are …
Nanoparticle delivery systems hold great potential to deliver these therapeutics but are …
The great escape: how cationic polyplexes overcome the endosomal barrier
The targeted and efficiency-oriented delivery of (therapeutic) nucleic acids raises hope for
successful gene therapy, ie, for the local and individual treatment of acquired and inherited …
successful gene therapy, ie, for the local and individual treatment of acquired and inherited …
Esca** the endosome: assessing cellular trafficking mechanisms of non-viral vehicles
Non-viral vehicles hold therapeutic promise in advancing the delivery of a variety of cargos
in vitro and in vivo, including small molecule drugs, biologics, and especially nucleic acids …
in vitro and in vivo, including small molecule drugs, biologics, and especially nucleic acids …
[HTML][HTML] Engineering poly-and micelleplexes for nucleic acid delivery–A reflection on their endosomal escape
For the longest time, the field of nucleic acid delivery has remained skeptical whether or not
polycationic drug carrier systems would ever make it into clinical practice. Yet, with the …
polycationic drug carrier systems would ever make it into clinical practice. Yet, with the …
Non-viral delivery to enable genome editing
Genome-editing technologies such as zinc-finger nucleases (ZFNs), transcription activator-
like effector nucleases (TALENS), and the clustered regularly interspaced short palindromic …
like effector nucleases (TALENS), and the clustered regularly interspaced short palindromic …
Quantitating endosomal escape of a library of polymers for mRNA delivery
Endosomal escape is a key step for intracellular drug delivery of nucleic acids, but reliable
and sensitive methods for its quantitation remain an unmet need. In order to rationally …
and sensitive methods for its quantitation remain an unmet need. In order to rationally …
The next-generation DNA vaccine platforms and delivery systems: Advances, challenges and prospects
B Lu, JM Lim, B Yu, S Song, P Neeli… - Frontiers in …, 2024 - frontiersin.org
Vaccines have proven effective in the treatment and prevention of numerous diseases.
However, traditional attenuated and inactivated vaccines suffer from certain drawbacks such …
However, traditional attenuated and inactivated vaccines suffer from certain drawbacks such …
Past and current progress in the development of antiviral/antimicrobial polymer coating towards COVID-19 prevention: A Review
The astonishing outbreak of SARS-CoV-2 coronavirus, known as COVID-19, has attracted
numerous research interests, particularly regarding fabricating antimicrobial surface …
numerous research interests, particularly regarding fabricating antimicrobial surface …