Chronic kidney disease (CKD) is estimated to affect 10–14% of global population. Kidney
fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a …

The field of single-cell genomics and spatial technologies is rapidly evolving and has
already provided unprecedented insights into complex tissues. Major advances have been …

Immunoglobulin A (IgA) is the most abundant isotype of antibodies, provides a first line of
defense at mucosal surfaces against pathogens, and thereby contributes to mucosal …

The kidney contains a population of resident macrophages from birth that expands as it
grows and forms a contiguous network throughout the tissue. Kidney-resident macrophages …

Autoimmunity refers to the phenomenon that the body's immune system produces antibodies
or sensitized lymphocytes to its own tissues to cause an immune response. Immune …

The deposition of immune complexes, activation of complement and infiltration of the kidney
by cells of the adaptive and innate immune systems have long been considered responsible …

Organ fibrogenesis is characterized by a common pathophysiological final pathway
independent of the underlying progressive disease of the respective organ. This makes it …

IgA nephropathy (IgAN) is characterized by glomerular deposition of immune complexes
(ICs) consisting of IgA1 with O-glycans deficient in galactose (Gd-IgA1) and Gd-IgA1-specific …

Idiopathic membranous nephropathy (IMN) is an organ-specific autoimmune disease of the
kidney glomerulus. It may gradually progress to end-stage renal disease (ESRD) …

Lab-on-a-chip tools have played a pivotal role in advancing modern biology and medicine.
A key goal in this field is to precisely transport single particles and cells to specific locations …