The distribution of fitness effects of new mutations
A Eyre-Walker, PD Keightley - Nature Reviews Genetics, 2007 - nature.com
The distribution of fitness effects (DFE) of new mutations is a fundamental entity in genetics
that has implications ranging from the genetic basis of complex disease to the stability of the …
that has implications ranging from the genetic basis of complex disease to the stability of the …
Hearing silence: non-neutral evolution at synonymous sites in mammals
Although the assumption of the neutral theory of molecular evolution—that some classes of
mutation have too small an effect on fitness to be affected by natural selection—seems …
mutation have too small an effect on fitness to be affected by natural selection—seems …
Searching for missing heritability: designing rare variant association studies
Genetic studies have revealed thousands of loci predisposing to hundreds of human
diseases and traits, revealing important biological pathways and defining novel therapeutic …
diseases and traits, revealing important biological pathways and defining novel therapeutic …
The QTN program and the alleles that matter for evolution: all that's gold does not glitter
MV Rockman - Evolution, 2012 - academic.oup.com
The search for the alleles that matter, the quantitative trait nucleotides (QTNs) that underlie
heritable variation within populations and divergence among them, is a popular pursuit. But …
heritable variation within populations and divergence among them, is a popular pursuit. But …
[KNJIGA][B] El origen de las especies
C Darwin - 2025 - books.google.com
Publicado en 1859, El origen de las especies de Charles Darwin llegó a ser conocido
como" el libro que sacudió al mundo". Su primera edición se agotó el primer día y lo mismo …
como" el libro que sacudió al mundo". Su primera edición se agotó el primer día y lo mismo …
Most rare missense alleles are deleterious in humans: implications for complex disease and association studies
The accumulation of mildly deleterious missense mutations in individual human genomes
has been proposed to be a genetic basis for complex diseases. The plausibility of this …
has been proposed to be a genetic basis for complex diseases. The plausibility of this …
Accelerated evolution of conserved noncoding sequences in humans
Changes in gene regulation likely influenced the profound phenotypic divergence of
humans from other mammals, but the extent of adaptive substitution in human regulatory …
humans from other mammals, but the extent of adaptive substitution in human regulatory …
Ultraconserved enhancer function does not require perfect sequence conservation
Ultraconserved enhancer sequences show perfect conservation between human and rodent
genomes, suggesting that their functions are highly sensitive to mutation. However, current …
genomes, suggesting that their functions are highly sensitive to mutation. However, current …
Human genome ultraconserved elements are ultraselected
Ultraconserved elements in the human genome are defined as stretches of at least 200 base
pairs of DNA that match identically with corresponding regions in the mouse and rat …
pairs of DNA that match identically with corresponding regions in the mouse and rat …
Tug-of-war between driver and passenger mutations in cancer and other adaptive processes
Cancer progression is an example of a rapid adaptive process where evolving new traits is
essential for survival and requires a high mutation rate. Precancerous cells acquire a few …
essential for survival and requires a high mutation rate. Precancerous cells acquire a few …