Barriers between circulation and the central nervous system (CNS) play a key role in the
development and modulation of CNS immune responses. Structural variations in the …

Malaria is a mosquito-borne disease caused by parasites of the obligate intracellular
Apicomplexa phylum the most deadly of which, Plasmodium falciparum, prevails in Africa …

Cerebral malaria (CM) caused by Plasmodium falciparum is a fatal neurological
complication of malaria, resulting in coma and death, and even survivors may suffer long …

Neuroinflammation is often associated with blood-brain-barrier dysfunction, which
contributes to neurological tissue damage. Here, we reveal the pathophysiology of Susac …

BACKGROUND Cerebral malaria (CM) accounts for nearly 400,000 deaths annually in
African children. Current dogma suggests that CM results from infected RBC (iRBC) …

Interferon gamma (IFN-γ) is a key mediator of inflammatory immune responses induced
primarily by interleukin-12 (IL-12). IFN-γ secretion by both innate and adaptive immune cells …

Coevolution of humans and malaria parasites has generated an intricate balance between
the immune system of the host and virulence factors of the parasite, equilibrating maximal …

Malaria, the most prevalent mosquito-borne infectious disease worldwide, has accompanied
humanity for millennia and remains an important public health issue despite advances in its …

Malaria is a highly prevalent disease caused by infection by Plasmodium spp., which infect
hepatocytes and erythrocytes. Blood-stage infections cause devastating symptoms and can …

Cerebral malaria (CM) is a severe complication of Plasmodium falciparum infection that
results in thousands of deaths each year, mostly in African children. The in vivo mechanisms …