▪ Abstract Both physiological cell death (apoptosis) and, in some cases, accidental cell death
(necrosis) involve a two-step process. At a first level, numerous physiological and some …

Arsenic is a trace element found in the earth, s crust at an average concentration of∼ 5 μg/g
(ppm). Although its relative abundance in the earth, s crust is about 54th, arsenic can …

During apoptosis, mitochondrial membrane permeability (MMP) increases and the release
into the cytosol of pro-apoptotic factors (procaspases, caspase activators and caspase …

Extracellular stimuli elicit a variety of responses, such as cell proliferation and differentiation,
through the cellular signalling system. Binding of growth factors to the respective receptor …

The glutathione (GSH) content of cancer cells is particularly relevant in regulating mutagenic
mechanisms, DNA synthesis, growth, and multidrug and radiation resistance. In malignant …

Apoptosis is a conserved homeostatic process critical for organ and tissue morphogenesis,
development, and senescence. This form of programmed cell death also participates in the …

Mitochondria are the main source of reactive oxygen species (ROS), most of them deriving
from the mitochondrial respiratory chain. Among the numerous enzymatic and non …

Scientific revolution [1] implies a transformation of the world view in which a dominant
paradigm is substituted by a new one, one which furnishes an ameliorated comprehension …

Activation of apoptosis is associated with generation of reactive oxygen species. The
present research shows that superoxide is produced by mitochondria isolated from apoptotic …

The primary objective of this study was to determine the sequence of biochemical signaling
events that occur after modulation of the cellular redox state in the B cell lymphoma line, PW …