Cationic lipids for gene delivery: Many players, one goal
Lipid-based carriers represent the most widely used alternative to viral vectors for gene
expression and gene silencing purposes. This class of non-viral vectors is particularly …
expression and gene silencing purposes. This class of non-viral vectors is particularly …
The headgroup evolution of cationic lipids for gene delivery
D Zhi, S Zhang, S Cui, Y Zhao, Y Wang… - Bioconjugate …, 2013 - ACS Publications
Cationic lipids are one of the most widely used nonviral vectors for gene delivery and are
especially attractive because they can be easily synthesized and extensively characterized …
especially attractive because they can be easily synthesized and extensively characterized …
Lipoplex morphologies and their influences on transfection efficiency in gene delivery
B Ma, S Zhang, H Jiang, B Zhao, H Lv - Journal of Controlled Release, 2007 - Elsevier
Cationic lipid-mediated gene transfer is widely used for their advantages over viral gene
transfer because it is non-immunogenic, easy to produce and not oncogenic. The main …
transfer because it is non-immunogenic, easy to produce and not oncogenic. The main …
The design of cationic lipids for gene delivery
B Martin, M Sainlos, A Aissaoui… - Current …, 2005 - ingentaconnect.com
Synthetic gene delivery vectors are gaining increasing importance in gene therapy as an
alternative to recombinant viruses. Among the various types of non-viral vectors, cationic …
alternative to recombinant viruses. Among the various types of non-viral vectors, cationic …
DOTAP (and other cationic lipids): chemistry, biophysics, and transfection
Cationic lipid-mediated nucleic acid and protein delivery is becoming increasingly popular
for in vitro and in vivo applications. While the chemistry of cationic lipid carriers is moving …
for in vitro and in vivo applications. While the chemistry of cationic lipid carriers is moving …
Biological activities of guanidine compounds
F Saczewski, Ł Balewski - Expert opinion on therapeutic patents, 2009 - Taylor & Francis
Background: The guanidine group defines chemical and physicochemical properties of
many compounds of medical interest and guanidine-containing derivatives constitute a very …
many compounds of medical interest and guanidine-containing derivatives constitute a very …
Structure-activity relationship in cationic lipid mediated gene transfection
D Niculescu-Duvaz, J Heyes… - Current medicinal …, 2003 - ingentaconnect.com
Non-viral synthetic vectors for gene delivery represent a safer alternative to viral vectors.
Their main drawback is the low transfection efficiency, especially in vivo. Among the non …
Their main drawback is the low transfection efficiency, especially in vivo. Among the non …
Synthetic nucleic acid delivery systems: present and perspectives
Self-assembled synthetic gene delivery systems represent the bottom-up approach to gene
delivery and gene silencing, in which scientists are designing novel cationic and procationic …
delivery and gene silencing, in which scientists are designing novel cationic and procationic …
Thiocholesterol-based lipids for ordered assembly of bioresponsive gene carriers
A series of thiocholesterol-based cationic lipids (TCL) has been designed and synthesized
by the attachment of thiocholesterol to a cationic amine via a disulfide bond. TCL can be …
by the attachment of thiocholesterol to a cationic amine via a disulfide bond. TCL can be …
Lipophilic pyrylium salts in the synthesis of efficient pyridinium-based cationic lipids, gemini surfactants, and lipophilic oligomers for gene delivery
MA Ilies, WA Seitz, BH Johnson, EL Ezell… - Journal of medicinal …, 2006 - ACS Publications
Several new classes of pyridinium cationic lipids were synthesized and tested as gene
delivery agents. They were obtained through a procedure that generates simultaneously the …
delivery agents. They were obtained through a procedure that generates simultaneously the …