Pre-eclampsia is a life-threatening disease of pregnancy unique to humans and a leading
cause of maternal and neonatal morbidity and mortality. Women who survive pre-eclampsia …

4. There are significant long-term cardiovascular risks for women with chronic hypertension
and those who have had gestational hypertension or preeclampsia. One initial …

Early-onset preeclampsia has been linked to poor placentation and fetal growth restriction,
whereas late-onset preeclampsia was suggested to result from maternal factors. We have …

Physiological transformation with remodeling of the uteroplacental spiral arteries is key to a
successful placentation and normal placental function. It is an intricate process that involves …

Preeclampsia is a disease whose characterization has not changed in the 150 years since
the cluster of signs associated with the disorder were first described. Although our …

Background The ratio of soluble fms-like tyrosine kinase 1 (sFlt-1) to placental growth factor
(PlGF) is elevated in pregnant women before the clinical onset of preeclampsia, but its …

Among mammalian species, human reproduction has 2 outstanding features. The human
hemochorial placentation is characterized by a very deep endovascular trophoblast invasion …

There has never been a definite consensus on the classification and diagnostic criteria for
the hypertensive disorders of pregnancy. This uncertainty is likely to have led to between …

Objective To estimate the contributions of biological aging, historical trends, and birth cohort
effects on trends in pre-eclampsia in the United States. Design Population based …

La preeclampsia constituye un problema de salud pública en medicina materno perinatal y
el reconocimiento de los factores de riesgo es de vital importancia para su manejo inicial …