Oxidative stress in neurodegenerative diseases
E Niedzielska, I Smaga, M Gawlik, A Moniczewski… - Molecular …, 2016 - Springer
The pathophysiologies of neurodegenerative diseases, including amyotrophic lateral
sclerosis (ALS), Parkinson's disease (PD), and Alzheimer's disease (AD), are far from being …
sclerosis (ALS), Parkinson's disease (PD), and Alzheimer's disease (AD), are far from being …
Redox dysregulation as a driver for DNA damage and its relationship to neurodegenerative diseases
Redox homeostasis refers to the balance between the production of reactive oxygen species
(ROS) as well as reactive nitrogen species (RNS), and their elimination by antioxidants. It is …
(ROS) as well as reactive nitrogen species (RNS), and their elimination by antioxidants. It is …
Metabolomics of human brain aging and age-related neurodegenerative diseases
Neurons in the mature human central nervous system (CNS) perform a wide range of motor,
sensory, regulatory, behavioral, and cognitive functions. Such diverse functional output …
sensory, regulatory, behavioral, and cognitive functions. Such diverse functional output …
C9ORF72 GGGGCC Expanded Repeats Produce Splicing Dysregulation which Correlates with Disease Severity in Amyotrophic Lateral Sclerosis
J Cooper-Knock, JJ Bury, PR Heath, M Wyles… - PloS one, 2015 - journals.plos.org
Objective An intronic GGGGCC-repeat expansion of C9ORF72 is the most common genetic
variant of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. The mechanism …
variant of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. The mechanism …
SOD1 in ALS: taking stock in pathogenic mechanisms and the role of glial and muscle cells
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by
the loss of motor neurons in the brain and spinal cord. While the exact causes of ALS are still …
the loss of motor neurons in the brain and spinal cord. While the exact causes of ALS are still …
The unfolded protein response and the role of protein disulfide isomerase in neurodegeneration
The maintenance and regulation of proteostasis is a critical function for post-mitotic neurons
and its dysregulation is increasingly implicated in neurodegenerative diseases. Despite …
and its dysregulation is increasingly implicated in neurodegenerative diseases. Despite …
Alterations in lipid metabolism of spinal cord linked to amyotrophic lateral sclerosis
AB Chaves-Filho, IFD Pinto, LS Dantas, AM Xavier… - Scientific reports, 2019 - nature.com
Amyotrophic lateral sclerosis (ALS) is characterized by progressive loss of upper and lower
motor neurons leading to muscle paralysis and death. While a link between dysregulated …
motor neurons leading to muscle paralysis and death. While a link between dysregulated …
The NRF2-dependent transcriptional regulation of antioxidant defense pathways: Relevance for cell type-specific vulnerability to neurodegeneration and therapeutic …
SM Boas, KL Joyce, RM Cowell - Antioxidants, 2021 - mdpi.com
Oxidative stress has been implicated in the etiology and pathobiology of various
neurodegenerative diseases. At baseline, the cells of the nervous system have the capability …
neurodegenerative diseases. At baseline, the cells of the nervous system have the capability …
Impact of reactive species on amino acids—biological relevance in proteins and induced pathologies
CMC Andrés, JM Pérez de la Lastra… - International Journal of …, 2022 - mdpi.com
This review examines the impact of reactive species RS (of oxygen ROS, nitrogen RNS and
halogens RHS) on various amino acids, analyzed from a reactive point of view of how during …
halogens RHS) on various amino acids, analyzed from a reactive point of view of how during …
Panel of oxidative stress and inflammatory biomarkers in ALS: a pilot study
H Blasco, G Garcon, F Patin… - Canadian Journal of …, 2017 - cambridge.org
Background: Pathophysiological mechanisms that contribute to neurodegeneration in
Amyotrophic Lateral Sclerosis (ALS) include oxidative stress and inflammation. We …
Amyotrophic Lateral Sclerosis (ALS) include oxidative stress and inflammation. We …