The incidence of non-alcoholic fatty liver disease (NAFLD) has increased significantly over
the past two decades. NAFLD ranges from simple steatosis (NAFL) to nonalcoholic …

Fungal infections are an increasing threat to global public health. There are more than six
million fungal species worldwide, but less than 1% are known to infect humans. Most of …

Polysaccharide capsule is the main virulence factor of K. pneumoniae, a major pathogen of
bloodstream infections in humans. While more than 80 capsular serotypes have been …

Environmental pathogens move from ecological niches to mammalian hosts, requiring
adaptation to dramatically different environments. Microbes that disseminate farther …

Vaccination has substantially reduced the morbidity and mortality of bacterial diseases, but
mechanisms of vaccine-elicited pathogen clearance remain largely undefined. We report …

Candida species are common colonizers of the human skin, vagina, and the gut. As human
commensals, Candida species do not cause any notable damage in healthy individuals; …

Many encapsulated bacteria use capsules to cause invasive diseases. However, it remains
largely unknown how the capsules enhance bacterial virulence under in vivo infection …

Kupffer cells, the resident macrophages of the liver, comprise the largest pool of tissue
macrophages in the body. Within the liver sinusoids Kupffer cells perform functions common …

Vitamin D deficiency remains a global concern. This 'sunshine'vitamin is converted through
a multistep process to active 1, 25-dihydroxyvitamin D3 (1, 25D), the final step of which can …

The dimorphic fungus Candida albicans is both a harmless commensal organism on
mucosal surfaces and an opportunistic pathogen. Under certain predisposing conditions, the …