The treatment of acute ischemic stroke continues to advance. The mainstay of treatment
remains intravenous thrombolysis with alteplase. Recent studies demonstrated that later …

For over 40 years, attempts to develop treatments that protect neurons and other brain cells
against the cellular and biochemical consequences of cerebral ischaemia in acute …

The Stroke Treatment Academic Industry Roundtable XII included a workshop to discuss the
most promising approaches to improve outcome from acute stroke. The workshop brought …

Human diseases may be modeled in animals to allow preclinical assessment of putative
new clinical interventions. Recent, highly publicized failures of large clinical trials called into …

Importance Despite some promising preclinical and clinical data, it remains uncertain
whether remote ischemic conditioning (RIC) with transient cycles of limb ischemia and …

Importance Sublingual edaravone dexborneol, which can rapidly diffuse and be absorbed
through the oral mucosa after sublingual exposure, is a multitarget brain cytoprotection …

The neurovascular unit (NVU) is a conceptual framework that has been proposed to better
explain the relationships between the neural cells and blood vessels in the human brain …

We found that blood vitronectin (VTN) leaks into the brain and exacerbates tissue loss after
stroke by increasing pro-inflammatory IL-6 expression in female, but not male, mice. VTN …

Over decades, nearly all attempts to translate the benefits of therapeutic hypothermia in
stroke models of lower-order species to stroke patients have failed. Potentially overlooked …

Hypertension is the most prevalent modifiable risk factor for stroke and is associated with
worse functional outcomes. Pharmacological inhibition of histone deacetylases by …