Covering: up to April 2021 The bacterial cyclic depsipeptides FR900359 (FR) and YM-
254890 (YM) were shown to selectively inhibit Gαq proteins with high potency and selectivity …

Chromobacterium violaceum is an abundant component of the soil and water microbiota in
tropical and subtropical regions around the world. For many years, it was mainly known as a …

The study of chemical bioactivity in the rhizosphere has recently broadened to include
microbial metabolites, and their roles in niche construction and competition via growth …

The potent and selective Gq protein inhibitor depsipeptide FR900359 (FR), originally
discovered as the product of an uncultivable plant endosymbiont, is synthesized by a …

Pigments are compounds with highly diverse structures and wide uses, which production is
increasing worldwide. An eco-friendly method of bioproduction is to use the ability of some …

Abstract The Chromobacterium sp. Panama bacterium has in vivo and in vitro anti-
Plasmodium properties. To assess the nature of the Chromobacterium-produced anti …

Abstract The compound 2, 4-diacetylphloroglucinol (DAPG) is a broad-spectrum antibiotic
that is primarily produced by Pseudomonas spp. DAPG plays an important role in the …

Mosquito larvae continuously encounter microbes in their aquatic environment, which serve
as food and play a critical role in successful development. In previous work, we isolated a …

The cyclic depsipeptide FR900359 (FR) is derived from the soil bacterium Chromobacterium
vaccinii and known to bind Gq proteins of mammals and insects, thereby abolishing the …

Microbial secondary metabolites continue to provide a valuable source of both chemical
matter and inspiration for drug discovery in a broad range of therapeutic areas. Beyond this …