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Masters of misdirection: peptidoglycan glycosidases in bacterial growth
The dynamic composition of the peptidoglycan cell wall has been the subject of intense
research for decades, yet how bacteria coordinate the synthesis of new peptidoglycan with …
research for decades, yet how bacteria coordinate the synthesis of new peptidoglycan with …
Bacterial metabolism and susceptibility to cell wall-active antibiotics
Bacterial infections are increasingly resistant to antimicrobial therapy. Intense research
focus has thus been placed on identifying the mechanisms that bacteria use to resist killing …
focus has thus been placed on identifying the mechanisms that bacteria use to resist killing …
Control of bacterial cell wall autolysins by peptidoglycan crosslinking mode
To withstand their internal turgor pressure and external threats, most bacteria have a
protective peptidoglycan (PG) cell wall. The growth of this PG polymer relies on autolysins …
protective peptidoglycan (PG) cell wall. The growth of this PG polymer relies on autolysins …
Lytic transglycosylase repertoire diversity enables intrinsic antibiotic resistance and daughter cell separation in Escherichia coli under acidic stress
Peptidoglycan (PG) is an important architectural element that imparts physical toughness
and rigidity to the bacterial envelope. It is also a dynamic structure that undergoes …
and rigidity to the bacterial envelope. It is also a dynamic structure that undergoes …
Peptidoglycan recycling mediated by an ABC transporter in the plant pathogen Agrobacterium tumefaciens
During growth and division, the bacterial cell wall peptidoglycan (PG) is remodelled,
resulting in the liberation of PG muropeptides which are typically reinternalized and …
resulting in the liberation of PG muropeptides which are typically reinternalized and …
Peptidoglycan recycling promotes outer membrane integrity and carbapenem tolerance in Acinetobacter baumannii
ABSTRACT β-Lactam antibiotics exploit the essentiality of the bacterial cell envelope by
perturbing the peptidoglycan layer, typically resulting in rapid lysis and death. Many Gram …
perturbing the peptidoglycan layer, typically resulting in rapid lysis and death. Many Gram …
Monitoring Drug–Protein Interactions in the Bacterial Periplasm by Solution Nuclear Magnetic Resonance Spectroscopy
The rapid spread of antimicrobial resistance across bacterial pathogens poses a serious risk
to the efficacy and sustainability of available treatments. This puts pressure on research …
to the efficacy and sustainability of available treatments. This puts pressure on research …
In vitro studies of the protein-interaction network of cell-wall lytic transglycosylase RlpA of Pseudomonas aeruginosa
The protein networks of cell-wall-biosynthesis assemblies are largely unknown. A key class
of enzymes in these assemblies is the lytic transglycosylases (LTs), of which eleven exist in …
of enzymes in these assemblies is the lytic transglycosylases (LTs), of which eleven exist in …
A potential space-making role in cell wall biogenesis for SltB1and DacB revealed by a beta-lactamase induction phenotype in Pseudomonas aeruginosa
Pseudomonas aeruginosa encodes the beta-lactamase AmpC, which promotes resistance
to beta-lactam antibiotics. Expression of ampC is induced by anhydro-muropeptides (AMPs) …
to beta-lactam antibiotics. Expression of ampC is induced by anhydro-muropeptides (AMPs) …
Amber‐codon suppression for spatial localization and in vivo photoaffinity capture of the interactome of the Pseudomonas aeruginosa rare lipoprotein A lytic …
The 11 lytic transglycosylases of Pseudomonas aeruginosa have overlap** activities in
the turnover of the cell‐wall peptidoglycan. Rare lipoprotein A (RlpA) is distinct among the …
the turnover of the cell‐wall peptidoglycan. Rare lipoprotein A (RlpA) is distinct among the …