The ability to design nanostructures with arbitrary shapes and controllable motions has
made DNA nanomaterials used widely to construct diverse nanomachines with various …

Under the selective pressure of therapy, tumours dynamically evolve multiple adaptive
mechanisms that make static interrogation of genomic alterations insufficient to guide …

Gastric cancer is a major source of global cancer mortality with limited treatment options and
poor patient survival. As our molecular understanding of gastric cancer improves, we are …

Abstract MicroRNAs (miRNAs), small non-coding RNAs approximately 20–25 nt in length,
play important roles via directly binding to the corresponding 3′ UTR of target mRNAs …

Rationale: In combination chemotherapy, the molar ratio of drugs is a critical parameter that
determines the synergistic effects. However, most co-delivery vectors are incapable of …

The increasing number of available anti-cancer drugs presents a challenge for oncologists,
who must choose the most effective treatment for the patient. Precision cancer medicine …

The mesenchymal cancer phenotype is known to be clinically related to treatment resistance
and a poor prognosis. We identified gene signature-based molecular subtypes of gastric …

This study addresses the demand for research models that can support patient-treatment
decisions and clarify the complexities of a tumor microenvironment by develo** an …

Esophageal squamous-cell carcinoma (ESCC) is commonly treated with radiotherapy;
however, radioresistance hinders its clinical effectiveness, and the underlying mechanism …

Nucleoside-based drugs, recognized as purine or pyrimidine analogs, have been potent
therapeutic agents since their introduction in 1950, deployed widely in the treatment of …