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Macrophage autophagy in macrophage polarization, chronic inflammation and organ fibrosis
JH Wen, DY Li, S Liang, C Yang, JX Tang… - Frontiers in …, 2022 - frontiersin.org
As the essential regulators of organ fibrosis, macrophages undergo marked phenotypic and
functional changes after organ injury. These changes in macrophage phenotype and …
functional changes after organ injury. These changes in macrophage phenotype and …
Extracellular vesicles and particles impact the systemic landscape of cancer
Intercellular cross talk between cancer cells and stromal and immune cells is essential for
tumor progression and metastasis. Extracellular vesicles and particles (EVPs) are a …
tumor progression and metastasis. Extracellular vesicles and particles (EVPs) are a …
Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein
ABSTRACT KRAS is the most frequently mutated oncogene in human neoplasia. Despite a
large investment to understand the effects of KRAS mutation in cancer cells, the direct effects …
large investment to understand the effects of KRAS mutation in cancer cells, the direct effects …
Dysfunction of autophagy in high-fat diet-induced non-alcoholic fatty liver disease
Q Ren, Q Sun, J Fu - Autophagy, 2024 - Taylor & Francis
Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases
with a global rising prevalence, which is closely associated with a high-fat diet (HFD) intake …
with a global rising prevalence, which is closely associated with a high-fat diet (HFD) intake …
LYC inhibits the AKT signaling pathway to activate autophagy and ameliorate TGFB-induced renal fibrosis
Y Wang, Z **, H Gao, Z Liu, Q Xv, X Jiang, W Yu - Autophagy, 2024 - Taylor & Francis
Renal fibrosis is a typical pathological change in chronic kidney disease (CKD). Epithelial-
mesenchymal transition (EMT) is the predominant stage. Activation of macroautophagy …
mesenchymal transition (EMT) is the predominant stage. Activation of macroautophagy …
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …
Since then, this topic has received increasing attention, and many scientists have entered …
[HTML][HTML] Guidelines for the use and interpretation of assays for monitoring autophagy 1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah… - …, 2021 - pmc.ncbi.nlm.nih.gov
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …
Since then, this topic has received increasing attention, and many scientists have entered …
[HTML][HTML] The effects of metformin on autophagy
G Lu, Z Wu, J Shang, Z **e, C Chen - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Metformin is the first-line option for treating newly diagnosed diabetic patients and also
involved in other pharmacological actions, including antitumor effect, anti-aging effect …
involved in other pharmacological actions, including antitumor effect, anti-aging effect …
Berberine alleviates liver fibrosis through inducing ferrous redox to activate ROS-mediated hepatic stellate cells ferroptosis
J Yi, S Wu, S Tan, Y Qin, X Wang, J Jiang, H Liu… - Cell death …, 2021 - nature.com
Berberine (BBR) has been explored as a potential anti-liver fibrosis agent, but the
underlying mechanisms are unknown. In the current study, we aimed to investigate the …
underlying mechanisms are unknown. In the current study, we aimed to investigate the …
Pancreatic β cell microRNA-26a alleviates type 2 diabetes by improving peripheral insulin sensitivity and preserving β cell function
H Xu, X Du, J Xu, Y Zhang, Y Tian, G Liu, X Wang… - PLoS …, 2020 - journals.plos.org
Type 2 diabetes (T2D) is characterized by insulin resistance along with pancreatic β cell
failure. β cell factors are traditionally thought to control glucose homeostasis by modulating …
failure. β cell factors are traditionally thought to control glucose homeostasis by modulating …