Vaccine adjuvants: mechanisms and platforms

T Zhao, Y Cai, Y Jiang, X He, Y Wei, Y Yu… - Signal transduction and …, 2023 - nature.com
Adjuvants are indispensable components of vaccines. Despite being widely used in
vaccines, their action mechanisms are not yet clear. With a greater understanding of the …

The use of RNA-based treatments in the field of cancer immunotherapy

M Chehelgerdi, M Chehelgerdi - Molecular Cancer, 2023 - Springer
Over the past several decades, mRNA vaccines have evolved from a theoretical concept to a
clinical reality. These vaccines offer several advantages over traditional vaccine techniques …

Nanocarriers address intracellular barriers for efficient drug delivery, overcoming drug resistance, subcellular targeting and controlled release

J Liu, H Cabral, P Mi - Advanced Drug Delivery Reviews, 2024 - Elsevier
The cellular barriers are major bottlenecks for bioactive compounds entering into cells to
accomplish their biological functions, which limits their biomedical applications …

Inhaled SARS-CoV-2 vaccine for single-dose dry powder aerosol immunization

T Ye, Z Jiao, X Li, Z He, Y Li, F Yang, X Zhao, Y Wang… - Nature, 2023 - nature.com
The COVID-19 pandemic has fostered major advances in vaccination technologies,,–;
however, there are urgent needs for vaccines that induce mucosal immune responses and …

Bioinspired and biomimetic delivery platforms for cancer vaccines

J Liu, SS Liew, J Wang, K Pu - Advanced Materials, 2022 - Wiley Online Library
Cancer vaccines aim at eliciting tumor‐specific responses for the immune system to identify
and eradicate malignant tumor cells while sparing the normal tissues. Furthermore, cancer …

Exosome-loaded degradable polymeric microcapsules for the treatment of vitreoretinal diseases

H Bao, Y Tian, H Wang, T Ye, S Wang, J Zhao… - Nature Biomedical …, 2024 - nature.com
The therapeutic benefits of many cell types involve paracrine mechanisms. Inspired by the
paracrine functions of exosomes and the sustained degradation properties of …

Hyperbaric oxygen enhances tumor penetration and accumulation of engineered bacteria for synergistic photothermal immunotherapy

KF Xu, SY Wu, Z Wang, Y Guo, YX Zhu, C Li… - Nature …, 2024 - nature.com
Bacteria-mediated cancer therapeutic strategies have attracted increasing interest due to
their intrinsic tumor tropism. However, bacteria-based drugs face several challenges …

Polymeric nanoparticle-based nanovaccines for cancer immunotherapy

Y Zhang, J Chen, L Shi, F Ma - Materials Horizons, 2023 - pubs.rsc.org
Therapeutic cancer vaccines, which are designed to amplify tumor-specific T cell responses,
have been envisioned as one of the most powerful tools for effective cancer immunotherapy …

The Development of Chiral Nanoparticles to Target NK Cells and CD8+ T Cells for Cancer Immunotherapy

W Wang, J Zhao, C Hao, S Hu, C Chen… - Advanced …, 2022 - Wiley Online Library
The chirality of nanomaterials (nanoparticles, NPs) can influence their interaction with cells
and biological systems. However, how chirality can exert impact on the immune response …

Antibody-based drug delivery systems for cancer therapy: Mechanisms, challenges, and prospects

Z Chen, RK Kankala, Z Yang, W Li, S **e, H Li… - …, 2022 - pmc.ncbi.nlm.nih.gov
In recent years, antibody-based cancer therapy has emerged as one of the efficient
therapeutic strategies, such as immune checkpoint inhibitors (ICIs), angiogenesis inhibitors …