Metabolic engineering has allowed the production of a diverse number of valuable
chemicals using microbial organisms. Many biological challenges for improving bio …

The past several years have witnessed an increased presence of control theoretic concepts
in synthetic biology. This review presents an organized summary of how these control …

Highlights•Synthetic biology provides new tools for the dynamic control of
metabolism.•Dynamic control is crucial to further the field of metabolic engineering.•Sensors …

Highlights•Engineered cell experiences metabolic imbalance with reduced fitness.•
Overproduction phenotype requires dynamic redistribution of cellular resource.•Metabolite …

Unnatural gene expression imposes a load on engineered microorganisms which
decreases their growth and subsequent production yields, a phenomenon known as burden …

Synthetic biology approaches to bioremediation are a key sustainable strategy to leverage
the self-replicating and programmable aspects of biology for environmental stewardship …

Malonyl-CoA is the basic building block for synthesizing a range of important compounds
including fatty acids, phenylpropanoids, flavonoids and non-ribosomal polyketides …

The rise of human populations and the growth of cities contribute to the depletion of natural
resources, increase their cost, and create potential climatic changes. To overcome …

Abstract 2016, was the 100 years anniversary from launching of the first industrial acetone-
butanol-ethanol (ABE) microbial production process. Despite this long period and also …

Microbes can be engineered to produce next-generation biofuels; however, the
accumulation of toxic biofuels can limit yields. Previous studies have shown that efflux …