The evolution of insecticide resistance is generally thought to be associated with a fitness
cost in the absence of insecticide exposure. However, it is not clear how these fitness costs …

Herbicide resistance is the ultimate evidence of the extraordinary capacity of weeds to
evolve under stressful conditions. Despite the extraordinary plant fitness advantage …

Adaptive therapy seeks to exploit intratumoral competition to avoid, or at least delay, the
emergence of therapy resistance in cancer. Motivated by promising results in prostate …

Much of what we know about the genetic basis of herbicide resistance has come from
detailed investigations of monogenic adaptation at known target‐sites, despite the …

Predicting mutational effects is essential for the control of antibiotic resistance (ABR).
Predictions are difficult when there are strong genotype-by-environment (G× E), gene-by …

Abstract BACKGROUND Spodoptera frugiperda (JE Smith) is a difficult pest to manage
mainly because of its resistance to insecticides and Bt proteins. We evaluated fitness costs …

Adaptive therapies that alternate between drug applications and drug-free vacations can
exploit competition between sensitive and resistant cells to maximize the time to …

Understanding the spatiotemporal dynamics of pesticide resistance at the landscape scale
is essential to anticipate the evolution and spread of new resistance phenotypes. In crop …

Antibiotic combination therapies are an approach used to counter the evolution of
resistance; their purported benefit is they can stop the successive emergence of …

The control of the Mediterranean fruit fly (Medfly), Ceratitis capitata, in citrus orchards in
Spain is mainly based in three insecticides (spinosad, lambda-cyhalothrin and deltamethrin) …