Auditory neuropathy—neural and synaptic mechanisms
Sensorineural hearing impairment is the most common form of hearing loss, and
encompasses pathologies of the cochlea and the auditory nerve. Hearing impairment …
encompasses pathologies of the cochlea and the auditory nerve. Hearing impairment …
Sensory processing at ribbon synapses in the retina and the cochlea
In recent years, sensory neuroscientists have made major efforts to dissect the structure and
function of ribbon synapses which process sensory information in the eye and ear. This …
function of ribbon synapses which process sensory information in the eye and ear. This …
Neuronal heterogeneity and stereotyped connectivity in the auditory afferent system
Spiral ganglion (SG) neurons of the cochlea convey all auditory inputs to the brain, yet the
cellular and molecular complexity necessary to decode the various acoustic features in the …
cellular and molecular complexity necessary to decode the various acoustic features in the …
Targeting dysregulation of redox homeostasis in noise-induced hearing loss: oxidative stress and ROS signaling
AR Fetoni, F Paciello, R Rolesi, G Paludetti… - Free Radical Biology and …, 2019 - Elsevier
Hearing loss caused by exposure to recreational and occupational noise remains a
worldwide disabling condition and dysregulation of redox homeostasis is the hallmark of …
worldwide disabling condition and dysregulation of redox homeostasis is the hallmark of …
Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse
The auditory inner hair cell (IHC) ribbon synapse operates with an exceptional temporal
precision and maintains a high level of neurotransmitter release. However, the molecular …
precision and maintains a high level of neurotransmitter release. However, the molecular …
Hair cell transduction, tuning, and synaptic transmission in the mammalian cochlea
R Fettiplace - Comprehensive Physiology, 2011 - Wiley Online Library
Sound pressure fluctuations striking the ear are conveyed to the cochlea, where they vibrate
the basilar membrane on which sit hair cells, the mechanoreceptors of the inner ear …
the basilar membrane on which sit hair cells, the mechanoreceptors of the inner ear …
Diversity matters—extending sound intensity coding by inner hair cells via heterogeneous synapses
Our sense of hearing enables the processing of stimuli that differ in sound pressure by more
than six orders of magnitude. How to process a wide range of stimulus intensities with …
than six orders of magnitude. How to process a wide range of stimulus intensities with …
The diverse roles of ribbon synapses in sensory neurotransmission
G Matthews, P Fuchs - Nature Reviews Neuroscience, 2010 - nature.com
Sensory synapses of the visual and auditory systems must faithfully encode a wide dynamic
range of graded signals, and must be capable of sustained transmitter release over long …
range of graded signals, and must be capable of sustained transmitter release over long …
[HTML][HTML] Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3
The expression of unconventional vesicular glutamate transporter VGLUT3 by neurons
known to release a different classical transmitter has suggested novel roles for signaling by …
known to release a different classical transmitter has suggested novel roles for signaling by …
Tuning of synapse number, structure and function in the cochlea
AC Meyer, T Frank, D Khimich, G Hoch, D Riedel… - Nature …, 2009 - nature.com
Cochlear inner hair cells (IHCs) transmit acoustic information to spiral ganglion neurons
through ribbon synapses. Here we have used morphological and physiological techniques …
through ribbon synapses. Here we have used morphological and physiological techniques …