Biomolecular simulations: recent developments in force fields, simulations of enzyme catalysis, protein-ligand, protein-protein, and protein-nucleic acid noncovalent …

W Wang, O Donini, CM Reyes… - Annual review of …, 2001 - annualreviews.org
▪ Abstract Computer modeling has been developed and widely applied in studying
molecules of biological interest. The force field is the cornerstone of computer simulations …

Long-range distance determinations in biomacromolecules by EPR spectroscopy

O Schiemann, TF Prisner - Quarterly reviews of biophysics, 2007 - cambridge.org
Electron paramagnetic resonance (EPR) spectroscopy provides a variety of tools to study
structures and structural changes of large biomolecules or complexes thereof. In order to …

The complete atomic structure of the large ribosomal subunit at 2.4 Å resolution

N Ban, P Nissen, J Hansen, PB Moore, TA Steitz - Science, 2000 - science.org
The large ribosomal subunit catalyzes peptide bond formation and binds initiation,
termination, and elongation factors. We have determined the crystal structure of the large …

When will RNA get its AlphaFold moment?

B Schneider, BA Sweeney, A Bateman… - Nucleic Acids …, 2023 - academic.oup.com
The protein structure prediction problem has been solved for many types of proteins by
AlphaFold. Recently, there has been considerable excitement to build off the success of …

Crystal structure of the ribosome at 5.5 Å resolution

MM Yusupov, GZ Yusupova, A Baucom, K Lieberman… - science, 2001 - science.org
We describe the crystal structure of the complete Thermus thermophilus 70 S ribosome
containing bound messenger RNA and transfer RNAs (tRNAs) at 5.5 angstrom resolution …

Structure of the 30S ribosomal subunit

BT Wimberly, DE Brodersen, WM Clemons Jr… - Nature, 2000 - nature.com
Genetic information encoded in messenger RNA is translated into protein by the ribosome,
which is a large nucleoprotein complex comprising two subunits, denoted 30S and 50S in …

Structure of functionally activated small ribosomal subunit at 3.3 Å resolution

F Schluenzen, A Tocilj, R Zarivach, J Harms… - cell, 2000 - cell.com
The small ribosomal subunit performs the decoding of genetic information during translation.
The structure of that from Thermus thermophilus shows that the decoding center, which …

Single-particle electron cryo-microscopy: towards atomic resolution

M Van Heel, B Gowen, R Matadeen… - Quarterly reviews of …, 2000 - cambridge.org
1. Introduction 3082. Electron microscopy 3112.1 Specimen preparation 3112.2 The
electron microscope 3112.3 Acceleration voltage, defocus, and the electron gun 3122.4 …

[HTML][HTML] Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3

M Pioletti, F Schlünzen, J Harms, R Zarivach… - The EMBO …, 2001 - embopress.org
The small ribosomal subunit is responsible for the decoding of genetic information and plays
a key role in the initiation of protein synthesis. We analyzed by X‐ray crystallography the …

[HTML][HTML] The use of polyoxometalates in protein crystallography–An attempt to widen a well-known bottleneck

A Bijelic, A Rompel - Coordination Chemistry Reviews, 2015 - Elsevier
Polyoxometalates (POMs) are discrete polynuclear metal-oxo anions with a fascinating
variety of structures and unique chemical and physical properties. Their application in …