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Therapeutic strategies for COVID-19: progress and lessons learned
G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
The SARS-CoV-2 nucleocapsid protein: its role in the viral life cycle, structure and functions, and use as a potential target in the development of vaccines and …
W Wu, Y Cheng, H Zhou, C Sun, S Zhang - Virology journal, 2023 - Springer
Abstract Coronavirus disease 2019 (COVID-19) continues to take a heavy toll on personal
health, healthcare systems, and economies around the globe. Scientists are expending …
health, healthcare systems, and economies around the globe. Scientists are expending …
The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods
Abstract ChEMBL (https://www. ebi. ac. uk/chembl/) is a manually curated, high-quality, large-
scale, open, FAIR and Global Core Biodata Resource of bioactive molecules with drug-like …
scale, open, FAIR and Global Core Biodata Resource of bioactive molecules with drug-like …
Liquid–liquid phase separation in human health and diseases
Emerging evidence suggests that liquid–liquid phase separation (LLPS) represents a vital
and ubiquitous phenomenon underlying the formation of membraneless organelles in …
and ubiquitous phenomenon underlying the formation of membraneless organelles in …
[HTML][HTML] SARS-CoV-2 disrupts host epigenetic regulation via histone mimicry
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged at the end of
2019 and caused the devastating global pandemic of coronavirus disease 2019 (COVID …
2019 and caused the devastating global pandemic of coronavirus disease 2019 (COVID …
Evolution of enhanced innate immune evasion by SARS-CoV-2
The emergence of SARS-CoV-2 variants of concern suggests viral adaptation to enhance
human-to-human transmission,. Although much effort has focused on the characterization of …
human-to-human transmission,. Although much effort has focused on the characterization of …
The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions
R Oughtred, J Rust, C Chang, BJ Breitkreutz… - Protein …, 2021 - Wiley Online Library
Abstract The BioGRID (Biological General Repository for Interaction Datasets, thebiogrid.
org) is an open‐access database resource that houses manually curated protein and …
org) is an open‐access database resource that houses manually curated protein and …
SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence
U Gioia, S Tavella, P Martínez-Orellana, G Cicio… - Nature Cell …, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the RNA virus
responsible for the coronavirus disease 2019 (COVID-19) pandemic. Although SARS-CoV-2 …
responsible for the coronavirus disease 2019 (COVID-19) pandemic. Although SARS-CoV-2 …
The immunology of multisystem inflammatory syndrome in children with COVID-19
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is typically very
mild and often asymptomatic in children. A complication is the rare multisystem inflammatory …
mild and often asymptomatic in children. A complication is the rare multisystem inflammatory …
[HTML][HTML] Identification of required host factors for SARS-CoV-2 infection in human cells
To better understand host-virus genetic dependencies and find potential therapeutic targets
for COVID-19, we performed a genome-scale CRISPR loss-of-function screen to identify …
for COVID-19, we performed a genome-scale CRISPR loss-of-function screen to identify …