The past decade has witnessed ongoing progress in precision medicine to improve human
health. As an emerging diagnostic technique, liquid biopsy can provide real-time …

Nucleic acids are considered as perfect programmable materials for cascade signal
amplification and not merely as genetic information carriers. Among them, catalytic hairpin …

Researchers have worked for many decades to master the rules of biomolecular design that
would allow artificial biopolymer complexes to self-assemble and function similarly to the …

Catalytic hairpin assembly (CHA) with advantages of high efficiency, flexible design, and
mild reaction condition is considered a promising molecular amplifier. Modified working …

Toehold-mediated strand displacement (TMSD) reactions between double-stranded DNA
and single-stranded oligonucleotides, which use a toehold structure as a switch, enable …

Rapid and accurate monitoring of cancer cells with high sensitivity is essential for a
successful cancer treatment. As high-affinity nucleic acid ligands, aptamers can improve the …

Biosensors have been commonly used in biomedical diagnostic tools in recent years,
because of a wide range of application, such as point-of-care monitoring of treatment and …

Owing to their high programmability and modularity, autonomous enzyme-free nucleic acid
circuits are attracting ever-growing interest as signal amplifiers with potential applications in …

The early detection of cancer favors a greater chance of curative treatment and long-term
survival. Exciting new technologies have been developed that can help to catch the disease …

Smart nanomaterials are nano-scaled materials that respond in a controllable and reversible
way to external physical or chemical stimuli. DNA self-assembly is an effective way to …