Late-stage retinal degenerative disease involving photoreceptor loss can be treated by
optogenetic therapy, cell transplantation and retinal prostheses. These approaches aim to …

Lipid nanoparticle (LNP)–based mRNA delivery holds promise for the treatment of inherited
retinal degenerations. Currently, LNP-mediated mRNA delivery is restricted to the retinal …

Despite being the most prevalent cause of inherited blindness in children, Stargardt disease
is yet to achieve the same clinical trial success as has been achieved for other inherited …

The discovery of the CRISPR/Cas system and its development into a powerful genome
engineering tool have revolutionized the field of molecular biology and generated …

Purpose: To expand the use of human retinal organoids from induced pluripotent stem cells
(iPSCs) as an in vitro model of the retina for assessing gene therapy treatments, it is …

Inherited and non-inherited retinopathies can affect distinct cell types, leading to progressive
cell death and visual loss. In the last years, new approaches have indicated exciting …

Pathogenic variants in the Crumbs homolog 1 (CRB1) gene lead to severe, childhood-onset
retinal degeneration leading to blindness in early adulthood. There are no approved …

The use of robotic surgery in ophthalmology has been shown to offer many potential
advantages to current surgical techniques. Vitreoretinal surgery requires complex …

The retina is one of the most complex and extraordinary human organs affected by genetic,
metabolic, and degenerative diseases, resulting in blindness for∼ 1.3 million people in the …

Non-viral gene therapy has the potential to overcome several shortcomings in viral vector-
based therapeutics. Methods of in vivo plasmid delivery have developed over recent years …