The organization of microtubule networks is crucial for controlling chromosome segregation
during cell division, for positioning and transport of different organelles, and for cell polarity …

Mathematical models are indispensable for disentangling the interactions through which
biological components work together to generate the forces and flows that position, mix, and …

Microtubule organization has a crucial role in regulating cell architecture. The geometry of
microtubule arrays strongly depends on the distribution of sites responsible for microtubule …

Chromosome segregation—the partitioning of genetic material into two daughter cells—is
one of the most crucial processes in cell division. In all Eukaryotes, chromosome …

Purpose Polo-like kinase 4 (PLK4) is a serine/threonine protein kinase that regulates
centriole duplication. PLK4 deregulation causes centrosome number abnormalities, mitotic …

The spindle shows remarkable diversity, and changes in an integrated fashion, as cells vary
over evolution. Here, we provide a mechanistic explanation for variations in the first mitotic …

Few techniques are available for studying the nature of forces that drive subcellular
dynamics. Here we develop two complementary ones. The first is femtosecond stereotactic …

The assembly of the mitotic spindle and the subsequent segregation of sister chromatids are
based on the self-organized action of microtubule filaments, motor proteins, and other …

Many types of large cells have multiple nuclei. In skeletal muscle fibers, the nuclei are
distributed along the cell to maximize their internuclear distances. This myonuclear …

The actin and microtubule cytoskeletons of mammalian oocytes and zygotes exist in distinct
forms at various subcellular locations. This enables each cytoskeletal system to perform …