Ageing is considered as a snowballing phenotype of the accumulation of damaged
dysfunctional or toxic proteins and silent mutations (polymorphisms) that sensitize relevant …

It has been nearly three decades since the budding yeast Saccharomyces cerevisiae
became a significant model organism for aging research and it has emerged as both simple …

Mitochondria are key organelles for cellular metabolism, and regulate several processes
including cell death and macroautophagy/autophagy. Here, we show that mitochondrial …

Perturbation of metabolism elicits cellular stress which profoundly modulates the cellular
proteome and thus protein homeostasis (proteostasis). Consequently, changes in the …

Once thought a mere ribosome factory, the nucleolus has been viewed in recent years as an
extremely sensitive gauge of diverse cellular stresses. Emerging concepts in nucleolar …

Transfer RNAs (tRNAs) mainly function as adapter molecules that decode messenger RNAs
(mRNAs) during protein translation by delivering amino acids to the ribosome. Traditionally …

The concept of ageing is one that has intrigued mankind since the beginning of time and is
now more important than ever as the incidence of age-related disorders is increasing in our …

The plasma membrane H+-ATPase Pma1 and the vacuolar V-ATPase act in close harmony
to tightly control pH homeostasis, which is essential for a vast number of physiological …

Different molecular signaling pathways, biological processes, and intercellular
communication mechanisms control longevity and are affected during cellular senescence …

Carbon metabolism is a crucial aspect of cell life. Glucose, as the primary source of energy
and carbon skeleton, determines the type of cell metabolism and biosynthetic capabilities …