Vitamin A or retinol is arguably the most multifunctional vitamin in the human body, as it is
essential from embryogenesis to adulthood. The pleiotropic effects of vitamin A are exerted …

Targeted drugs have changed cancer treatment but are often ineffective in the long term
against solid tumours, largely because of the activation of heterogeneous oncogenic …

Protein phosphorylation regulates many cellular processes by causing changes in protein
conformation. The prolyl isomerase PIN1 has been identified as a regulator of …

Proline is unique in the realm of amino acids in its ability to adopt completely distinct cis and
trans conformations, which allows it to act as a backbone switch that is controlled by prolyl …

Several epidemiological studies show an inverse association between cancer and
Alzheimer's disease (AD). It is debated whether this association is the consequence of …

The serine/threonine protein kinase B (PKB, also known as Akt) constitutes an important
node in diverse signaling cascades downstream of growth factor receptor tyrosine kinases …

The 66-kilodalton isoform of the growth factor adapter Shc (p66Shc) translates oxidative
damage into cell death by acting as reactive oxygen species (ROS) producer within …

The mitogen-activated protein kinases (MAPKs) are a family of serine/threonine kinases that
play an essential role in signal transduction by modulating gene transcription in the nucleus …

The cis-trans isomerization of proline serves as a regulatory switch in signaling pathways.
We identify the proline isomerase Fpr4, a member of the FK506 binding protein family in …

Gephyrin is a central element that anchors, clusters and stabilizes glycine and γ-
aminobutyric acid type A receptors at inhibitory synapses of the mammalian brain. It self …