Abstract Around 30–40% of patients with colorectal cancer (CRC) undergoing curative
resection of the primary tumour will develop metastases in the subsequent years. Therapies …

The potential existence and roles of the meningeal lymphatic system in normal and
pathological brain function have been a long-standing enigma. Recent evidence suggests …

The stem cells that maintain and repair the postnatal skeleton remain undefined. One model
suggests that perisinusoidal mesenchymal stem cells (MSCs) give rise to osteoblasts …

Our environment poses a constant threat to our health. To survive, all organisms must be
able to discriminate between good (food ingredients and microbes that help digest our food) …

Chinese hamster ovary (CHO) cells dominate biotherapeutic protein production and are
widely used in mammalian cell line engineering research. To elucidate metabolic …

Succinate is a signaling metabolite sensed extracellularly by succinate receptor 1
(SUNCR1). The accumulation of succinate in macrophages is known to activate a pro …

Microarray expression studies suffer from the problem of batch effects and other unwanted
variation. Many methods have been proposed to adjust microarray data to mitigate the …

In addition to genetic predisposition, environmental and lifestyle factors contribute to the
pathogenesis of type 2 diabetes (T2D). Epigenetic changes may provide the link for …

DNA replication in mammals is regulated via the coordinate firing of clusters of replicons that
duplicate megabase-sized chromosome segments at specific times during S-phase …

The cause of Crohn's disease (CD) remains poorly understood. Counterintuitively, these
patients possess an impaired acute inflammatory response, which could result in delayed …