With the advent of technologies to obtain the complete sequence of the human genome in a
cost-effective manner, this decade and those to come will see an exponential increase in our …

The introduction of light sheet fluorescence microscopy (LSFM) has overcome the
challenges in conventional optical microscopy. Among the recent breakthroughs in …

Oblique plane microscopy (OPM) directly captures object information in a plane tilted from
the focal plane of the objective lens without the need for slow z-stack acquisition. This …

Abstract Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) stimulates calcium
release from acidic stores such as lysosomes and is a highly potent calcium-mobilising …

With its conceptualisation nearly fifty years ago, cardiac mechano-electric coupling (MEC)
has developed from a collection of anecdotal reports into a field of research that–in spite of …

Computational models have become a fundamental tool in cardiac research. Models are
evolving to cover multiple scales and physical mechanisms. They are moving towards …

Knowledge of cardiomyocyte biology is limited by the lack of methods to interrogate single-
cell physiology in vivo. Here we show that contracting myocytes can indeed be imaged with …

Sarcomeric contraction in cardiomyocytes serves as the basis for the heart's pump functions
in mammals. Although it plays a critical role in the circulatory system, myocardial sarcomere …

Recent advances in intravital microscopy have provided insight into dynamic biological
events at the cellular level in both healthy and pathological tissue. However, real-time in vivo …

Cardiac excitation‐contraction (E‐C) coupling is influenced by (at least) three dynamic
systems that couple and feedback to one another (see Abstract Figure). Here we review the …