The extracellular matrix (ECM) is a salient feature of all solid tissues within the body. This
complex, acellular entity is composed of hundreds of individual molecules whose assembly …

Research on the epidermal growth factor (EGF) family and the family of receptors (EGFR)
has progressed rapidly in recent times. New crystal structures of the ectodomains with …

INTRODUCTION Our textbook understanding of the nanoscale organization of the cell and
its relationship to the thousands of proteins that drive cellular metabolism comes largely from …

The aggressive and rapidly lethal brain tumor glioblastoma (GBM) is associated with
profound tissue stiffening and genomic lesions in key members of the epidermal growth …

Herein we aimed to understand how nanoscale clustering of RGD ligands alters the
mechano-regulation of their integrin receptors. We combined molecular tension …

The aberrant regulation of PD‐L1 in tumor cells remains poorly understood. Here, the
authors systematically investigate the endosomal trafficking of plasma membrane PD‐L1 in …

Mammalian and bacterial cells sense and exert mechanical forces through the process of
mechanotransduction, which interconverts biochemical and physical signals. This is …

The nanoscale arrangement of ligands can have a major effect on the activation of
membrane receptor proteins and thus cellular communication mechanisms. Here we report …

Single-pass membrane receptors contain extracellular domains that respond to external
stimuli and transmit information to intracellular domains through a single transmembrane …

The spatial arrangement of the epidermal growth factor receptor (EGFR) on the cellular
plasma membrane is one of the prime factors that control its downstream signaling pathways …