Recent advances bioactive 1, 2, 4-triazole-3-thiones

ŞG Küçükgüzel, P Çıkla-Süzgün - European journal of medicinal chemistry, 2015 - Elsevier
Triazoles are heterocyclic compounds which have a five-membered ring of two carbon
atoms and three nitrogen atoms. These structures have been interest in the development of …

Chemistry and biological activities of 1, 2, 4-triazolethiones—antiviral and anti-infective drugs

AA Aly, A A. Hassan, MM Makhlouf, S Bräse - Molecules, 2020 - mdpi.com
Mercapto-substituted 1, 2, 4-triazoles are very interesting compounds as they play an
important role in chemopreventive and chemotherapeutic effects on cancer. In recent …

[HTML][HTML] Synthesis, biological evaluation and molecular docking study of pyrimidine based thiazolidinone derivatives as potential anti-urease and anti-cancer agents

S Khan, H Ullah, F Rahim, R Hussain, Y Khan… - Journal of Saudi …, 2023 - Elsevier
Hybrid analogs containing molecules are always the choice of different synthetic researcher
due to their diverse biological applications and significantly more efficient. Heterocyclic …

Triazolothiadiazoles and triazolothiadiazines as potent α-glucosidase inhibitors: Mechanistic insights from kinetics studies, molecular docking and dynamics …

S Ullah, M Waqas, SA Halim, I Khan, A Khalid… - International Journal of …, 2023 - Elsevier
Diabetes mellitus has been considered as a serious health problem worldwide due its high
prevalence rate and associated complications. In this context, the current research work …

[HTML][HTML] Identification of novel oxadiazole-based benzothiazole derivatives as potent inhibitors of α-glucosidase and urease: synthesis, in vitro bio-evaluation and their …

Y Khan, A Maalik, W Rehman, R Hussain… - Journal of Saudi …, 2023 - Elsevier
This research work represents a synthetic approach for the development of hybrids
derivatives of oxadiazole-based benzothiazole (1–17) and diversity in derivatives was …

[PDF][PDF] Chemistry of 1, 2, 4-triazole: a review article

JK Shneine, YH Alaraji - Spectroscopy, 2016 - researchgate.net
Triazole was first synthesized over a century ago, but still attracts attention of chemists,
biologists, technologists and other specialists. In recent years, antiviral, anti-inflammatory …

Antiureolytic activity of new water-soluble thiadiazole derivatives: Spectroscopic, DFT, and molecular docking studies

ZHJ Al-Qaisi, ZS Al-Garawi, AJM Al-Karawi… - … Acta Part A: Molecular …, 2022 - Elsevier
Two new water-soluble thiadiazole compounds are prepared and characterized with various
techniques. These compounds, 5-amino-1, 3, 4-thiadiazole hydrochloride (1) and 5-amino-3 …

Synthesis, crystal structure and biological evaluation of some novel 1, 2, 4-triazolo [3, 4-b]-1, 3, 4-thiadiazoles and 1, 2, 4-triazolo [3, 4-b]-1, 3, 4-thiadiazines

I Khan, S Zaib, A Ibrar, NH Rama, J Simpson… - European journal of …, 2014 - Elsevier
Nitrogen-containing heterocycles are of particular interest and significant importance for the
discovery of potent bioactive agents in pharmaceutical industry. The present study reports …

[HTML][HTML] [1, 2, 4] triazolo [3, 4-b][1, 3, 4] thiadiazole derivatives as new therapeutic candidates against urease positive microorganisms: design, synthesis …

MK Ghomi, M Noori, MN Montazer… - Scientific …, 2023 - ncbi.nlm.nih.gov
Regarding the important role of the urease enzyme as a virulence factor in urease-positive
microorganisms in this study, new series of [1, 2, 4] triazolo [3, 4-b][1, 3, 4] thiadiazole …

New triazinoindole bearing benzimidazole/benzoxazole hybrids analogs as potent inhibitors of urease: synthesis, in vitro analysis and molecular docking studies

S Mumtaz, S Iqbal, M Shah, R Hussain, F Rahim… - Molecules, 2022 - mdpi.com
Twenty-four analogs based on triazinoindole bearing benzimidazole/benzoxazole moieties
(1–25) were synthesized. Utilizing a variety of spectroscopic methods, including 1H-, 13C …