Eye development has been a paradigm for the study of organogenesis, from the
demonstration of lens induction through epithelial tissue morphogenesis, to neuronal …

Defects in pituitary gland organogenesis are sometimes associated with congenital
anomalies that affect head development. Lesions in transcription factors and signaling …

Diabetes is associated with β cell failure. But it remains unclear whether the latter results
from reduced β cell number or function. FoxO1 integrates β cell proliferation with adaptive β …

Ascertaining when and where genes are expressed is of crucial importance to
understanding or predicting the physiological role of genes and proteins and how they …

The suprachiasmatic nucleus (SCN), the primary circadian pacemaker in mammals, is a
network structure composed of multiple types of neurons. Here, we report that mice with a …

Here, we have addressed the mechanisms that determine genesis of the correct numbers of
neurons during development, focusing on the embryonic cortex. We identify in neural …

The medial habenula (MHb) is considered a brain center regulating aversive states. The mu
opioid receptor (MOR) has been traditionally studied at the level of nociceptive and …

Sister chromatid cohesion, mediated by cohesin and regulated by Sororin, is essential for
chromosome segregation. In mammalian cells, cohesion establishment and Sororin …

The development of neuronal networks in the neocortex depends on control mechanisms for
mitosis and migration that allow newborn neurons to find their accurate position. Multiple …

Mutations in the aristaless-related homeobox (ARX) gene are associated with multiple
neurologic disorders in humans. Studies in mice indicate Arx plays a role in neuronal …