Apoptosis-inducing factor (AIF) is a mitochondrial oxidoreductase that contributes to cell
death programmes and participates in the assembly of the respiratory chain. Importantly, AIF …

Mitochondria have multiple functions such as supplying energy, regulating the redox status,
and producing proteins encoded by an independent genome. They are closely related to the …

The majority of proteins localised to mitochondria are encoded by the nuclear genome, with
approximately 1500 proteins imported into mammalian mitochondria. Dysfunction in this …

Background Genetic mitochondrial diseases represent a significant challenge to human
health. These diseases are extraordinarily heterogeneous in clinical presentation and …

Apoptosis-inducing factor (AIF) is a mitochondrial intermembrane space flavoprotein with
diverse functions in cellular physiology. In this regard, a large number of studies have …

The mitochondrial intermembrane space (IMS) is the most constricted sub-mitochondrial
compartment, housing only about 5% of the mitochondrial proteome, and yet is endowed …

Background Excessive proliferation of pulmonary artery smooth muscle cells (PASMCs) is
the main cause of hypoxic pulmonary hypertension (PH), and mitochondrial homeostasis …

Background and Objective Apoptosis-inducing factor (AIF), a flavin protein in mitochondria,
is originally found to induce apoptosis under the stimulation of pro-apoptotic factors. As a …

In the mitochondria of healthy cells, Apoptosis-Inducing factor (AIF) is required for the
optimal functioning of the respiratory chain machinery, mitochondrial integrity, cell survival …

Genetic mutations in apoptosis-inducing factor (AIF) have a strong association with
mitochondrial disorders; however, little is known about the aberrant splicing variants in …