Capturing physiological hemodynamic flow and mechanosensitive cell signaling in vessel-on-a-chip platforms

A Martier, Z Chen, H Schaps, MJ Mondrinos… - Frontiers in …, 2024 - frontiersin.org
Recent advances in organ chip (or,“organ-on-a-chip”) technologies and microphysiological
systems (MPS) have enabled in vitro investigation of endothelial cell function in biomimetic …

Engineering Biomaterials to Model Immune‐Tumor Interactions In Vitro

A Skirzynska, C Xue, MS Shoichet - Advanced Materials, 2024 - Wiley Online Library
Engineered biomaterial scaffolds are becoming more prominent in research laboratories to
study drug efficacy for oncological applications in vitro, but do they have a place in …

A compartmentalized microfluidic platform to investigate immune cells cross-talk in rheumatoid arthritis

C Palma, B Aterini, E Ferrari, M Mangione… - …, 2024 - iopscience.iop.org
The dysregulation of the immune system plays a crucial role in the pathogenesis of manyfold
diseases, among which we find rheumatoid arthritis (RA), an autoimmune disease …

Modeling lung endothelial dysfunction in sepsis‐associated ARDS using a microphysiological system

NW Liang, C Wilson, B Davis, I Wolf, T Qyli… - Physiological …, 2024 - Wiley Online Library
Endothelial dysfunction is a critical feature of acute respiratory distress syndrome (ARDS)
associated with higher disease severity and worse outcomes. Preclinical in vivo models of …

Modeling cancer–microbiome interactions in vitro: A guide to co‐culture platforms

K Moskal, N Khurana, L Siegert, YS Lee… - … Journal of Cancer, 2024 - Wiley Online Library
The biology of cancer is characterized by an intricate interplay of cells originating not only
from the tumor mass, but also its surrounding environment. Different microbial species have …

In vitro immunity: an overview of immunocompetent organ-on-chip models

AI Morrison, MJ Sjoerds, LA Vonk, S Gibbs… - Frontiers in …, 2024 - frontiersin.org
Impressive advances have been made to replicate human physiology in vitro over the last
few years due to the growth of the organ-on-chip (OoC) field in both industrial and academic …

Biomaterials meet organ-on-chips–a perspective on tumor modeling

CF Monteiro, IA Deus, CA Custódio… - International Materials …, 2024 - journals.sagepub.com
Microfluidic organ-on-chip systems are promising platforms for the development of
biomimetic models that aim to reconstruct the 3D architecture and intrinsic functionality of …

Organ‐On‐A‐Chip Devices: Technology Progress and Challenges

PJ Obeid, P Yammine, H El‐Nakat, R Kassab… - …, 2024 - Wiley Online Library
Abstract Organ‐On‐a‐Chip (OOC) is a multichannel 3D‐microfluidic cell‐culture system
incorporated in a chip that simulates the behavior of an organ. This technology relies on a …

[HTML][HTML] Organ-on-a-Chip Applications in Microfluidic Platforms

L An, Y Liu, Y Liu - Micromachines, 2025 - mdpi.com
Microfluidic technology plays a crucial role in organ-on-a-chip (OoC) systems by replicating
human physiological processes and disease states, significantly advancing biomedical …

Advances in microfluidics for biomedical engineering applications

MS Razavi, A Nematollahzadeh - Advances in Separation Sciences, 2025 - Elsevier
Microfluidics technology has found numerous applications as an efficient and cost-effective
tool in biomedical engineering, where microfluidic devices have revolutionized biomedical …