Podophyllotoxin: history, recent advances and future prospects

Z Shah, UF Gohar, I Jamshed, A Mushtaq, H Mukhtar… - Biomolecules, 2021 - mdpi.com
Podophyllotoxin, along with its various derivatives and congeners are widely recognized as
broad-spectrum pharmacologically active compounds. Etoposide, for instance, is the …

Podophyllotoxin: distribution, sources, applications and new cytotoxic derivatives

M Gordaliza, PA Garcıa, JMM Del Corral, MA Castro… - Toxicon, 2004 - Elsevier
Several podophyllotoxin derivatives modified in the A, B, C, D and E rings were prepared
from podophyllotoxin and methyl isoxazopodophyllic acid and evaluated for their cytotoxicity …

Isolation and identification of an endophytic strain of Fusarium oxysporum producing podophyllotoxin from Juniperus recurva

A Kour, AS Shawl, S Rehman, P Sultan… - World Journal of …, 2008 - Springer
Podophyllotoxin, a well-known naturally occurring aryltetralin lignan occurs in few plant
species that is used as a precursor for the chemical synthesis of the anticancer drugs like …

Using micropropagation to develop medicinal plants into crops

RM Moraes, AL Cerdeira, MV Lourenço - Molecules, 2021 - mdpi.com
Medicinal plants are still the major source of therapies for several illnesses and only part of
the herbal products originates from cultivated biomass. Wild harvests represent the major …

Biotechnological aspects of the production of the anticancer drug podophyllotoxin

S Farkya, VS Bisaria, AK Srivastava - Applied microbiology and …, 2004 - Springer
The natural lignan podophyllotoxin, a dimerized product of two phenylpropanoid moieties
which occurs in a few plant species, is a pharmacologically important compound for its …

[HTML][HTML] Junipers of various origins as potential sources of the anticancer drug precursor podophyllotoxin

DI Ivanova, PT Nedialkov, AN Tashev, M Olech… - Molecules, 2021 - mdpi.com
Juniper representatives are natural sources of plenty of bioactive metabolites and have
been used since ancient times as folk remedies against tapeworms, warts, cancer, etc. The …

Biotechnological interventions for harnessing podophyllotoxin from plant and fungal species: current status, challenges, and opportunities for its commercialization

A Kumari, D Singh, S Kumar - Critical reviews in biotechnology, 2017 - Taylor & Francis
Podophyllotoxin is an aryltetralin lignan synthesized in several plant species, which is used
in chemotherapies for cancers and tumor treatment. More potent semisynthetic derivatives of …

Endophytic Fungus from Sinopodophyllum emodi (Wall.) Ying that Produces Podophyllotoxin

Z Liang, J Zhang, X Zhang, J Li… - Journal of …, 2016 - academic.oup.com
The aryltetralin lactone podophyllotoxin, which exhibits pronounced antineoplastic activity, is
used as the precursor of the following three clinical anticancer drugs: Etoposide™ …

[HTML][HTML] Investigation of Linum flavum (L.) Hairy Root Cultures for the Production of Anticancer Aryltetralin Lignans

S Renouard, C Corbin, S Drouet, B Medvedec… - International journal of …, 2018 - mdpi.com
Linum flavum hairy root lines were established from hypocotyl pieces using Agrobacterium
rhizogenes strains LBA 9402 and ATCC 15834. Both strains were effective for …

[LIBRO][B] North American cornucopia: top 100 indigenous food plants

E Small - 2013 - books.google.com
Many North American plants have characteristics that are especially promising for creating
varieties needed to expand food production, and there are excellent prospects of generating …