Hepatic fibrogenesis is a pathophysiological outcome of chronic liver injury hallmarked by
excessive accumulation of extracellular matrix proteins. Fibrosis is a dynamic process that …

Liver fibrosis is a clinically significant finding that has major impacts on patient morbidity and
mortality. The mechanism of fibrosis involves many different cellular pathways, but the major …

Interleukin-22 (IL-22) is a recently described IL-10 family cytokine that is produced by T
helper (Th) 17 cells, γδ T cells, NKT cells, and newly described innate lymphoid cells (ILCs) …

Members of the interleukin (IL)-10 family of cytokines play important roles in regulating
immune responses during host defense but also in autoimmune disorders, inflammatory …

Abstract Interleukin-22 (IL-22) is a key effector molecule that is produced by activated T cells,
including T helper 22 (TH22) cells, TH17 cells and TH1 cells, as well as subsets of innate …

Liver fibrosis occurs in response to any etiology of chronic liver injury including hepatitis B
and C, alcohol consumption, fatty liver disease, cholestasis, and autoimmune hepatitis …

The adult organism is characterized by remarkable plasticity, which enables efficient
regeneration and restoration of homeostasis after damage. When aberrantly activated, this …

Chronic liver injury with any etiology can progress to fibrosis and the end-stage diseases
cirrhosis and hepatocellular carcinoma. The progression of liver disease is controlled by a …

Inflammation entails a complex set of defense mechanisms acting in concert to restore the
homeostatic balance in organisms after damage or pathogen invasion. This immune …

Wound healing and tissue regeneration is an intricate biological process that involves repair
of cellular damage and maintenance of tissue integrity. Cascades involved in wound healing …