Mitochondrial proteins: from biogenesis to functional networks

N Pfanner, B Warscheid, N Wiedemann - Nature reviews Molecular cell …, 2019 - nature.com
Mitochondria are essential for the viability of eukaryotic cells as they perform crucial
functions in bioenergetics, metabolism and signalling and have been associated with …

Mitochondrial form and function

JR Friedman, J Nunnari - Nature, 2014 - nature.com
Mitochondria are one of the major ancient endomembrane systems in eukaryotic cells.
Owing to their ability to produce ATP through respiration, they became a driving force in …

Mitochondrial quality control in health and in Parkinson's disease

MA Eldeeb, RA Thomas, MA Ragheb… - Physiological …, 2022 - journals.physiology.org
As a central hub for cellular metabolism and intracellular signaling, the mitochondrion is a
pivotal organelle, dysfunction of which has been linked to several human diseases including …

[HTML][HTML] Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context

M Morgenstern, CD Peikert, P Lübbert, I Suppanz… - Cell metabolism, 2021 - cell.com
Mitochondria are key organelles for cellular energetics, metabolism, signaling, and quality
control and have been linked to various diseases. Different views exist on the composition of …

Mitochondria: in sickness and in health

J Nunnari, A Suomalainen - Cell, 2012 - cell.com
Mitochondria perform diverse yet interconnected functions, producing ATP and many
biosynthetic intermediates while also contributing to cellular stress responses such as …

Mitochondria as a cellular hub in infection and inflammation

P Andrieux, C Chevillard, E Cunha-Neto… - International journal of …, 2021 - mdpi.com
Mitochondria are the energy center of the cell. They are found in the cell cytoplasm as
dynamic networks where they adapt energy production based on the cell's needs. They are …

Structure and function of mitochondrial membrane protein complexes

W Kühlbrandt - BMC biology, 2015 - Springer
Biological energy conversion in mitochondria is carried out by the membrane protein
complexes of the respiratory chain and the mitochondrial ATP synthase in the inner …

Mitochondrial machineries for protein import and assembly

N Wiedemann, N Pfanner - Annual review of biochemistry, 2017 - annualreviews.org
Mitochondria are essential organelles with numerous functions in cellular metabolism and
homeostasis. Most of the> 1,000 different mitochondrial proteins are synthesized as …

Mitochondrial protein transport: Versatility of translocases and mechanisms

JD Busch, LF Fielden, N Pfanner, N Wiedemann - Molecular Cell, 2023 - cell.com
Biogenesis of mitochondria requires the import of approximately 1,000 different precursor
proteins into and across the mitochondrial membranes. Mitochondria exhibit a wide variety …

Lipids of mitochondria

SE Horvath, G Daum - Progress in lipid research, 2013 - Elsevier
A unique organelle for studying membrane biochemistry is the mitochondrion whose
functionality depends on a coordinated supply of proteins and lipids. Mitochondria are …