Originally developed and commercialized as an antiprotozoal agent, nitazoxanide was later
identified as a first-in-class broad-spectrum antiviral drug and has been repurposed for the …

Thiazole is one of the most important scaffolds in heterocyclic chemistry and drug design
and discovery. It is widely found in diverse pharmacologically active substances and in …

HBV infection is a major cause of liver cirrhosis and hepatocellular carcinoma. Although
HBV infection can be efficiently prevented by vaccination, and treatments are available, to …

Antiviral therapies are integral in the fight against SARS‐CoV‐2 (ie severe acute respiratory
syndrome coronavirus 2), the causative agent of COVID‐19. Antiviral therapeutics can be …

The rapidly growing COVID-19 pandemic is the most serious global health crisis since the
“Spanish flu” of 1918. There is currently no proven effective drug treatment or prophylaxis for …

Background: The thiazolide nitazoxanide (NTZ) is a broad-spectrum antiinfective drug that
adversely affects viability, growth, and proliferation of a range of extracellular and …

Covering: 1998 to 2011. Previous review: Nat. Prod. Rep., 1998, 15, 173–186The fourteen
years that have passed since the previous review on this topic have seen a significant …

Infectious diseases commonly occur in tropical and sub-tropical countries. The pathogens of
such diseases are able to multiply in human hosts, warranting their continual survival …

Tizoxanide is the main active metabolite of nitazoxanide. Nitazoxanide and tizoxanide have
a broad-spectrum anti-infective effect, including parasites, bacteria, and virus. In the present …

Niclosamide is an FDA-approved anthelmintic drug for the treatment of parasitic infections.
However, over the past few years, increasing evidence has shown that niclosamide could …