The development of animal embryos is initially directed by maternal gene products. Then,
during the maternal-to-zygotic transition (MZT), developmental control is handed to the …

A remarkable epigenetic remodelling process occurs shortly after fertilization, which restores
totipotency to the zygote. This involves global DNA demethylation, chromatin remodelling …

Zygotic genome activation (ZGA) is a critical postfertilization step that promotes totipotency
and allows different cell fates to emerge in the develo** embryo. MERVL (murine …

In mammals, translational control plays critical roles during oocyte-to-embryo transition
(OET) when transcription ceases. However, the underlying regulatory mechanisms remain …

In mammals, chromatin organization undergoes drastic reprogramming after fertilization.
However, the three-dimensional structure of chromatin and its reprogramming in …

In mammals, extensive chromatin reorganization is essential for reprogramming terminally
committed gametes to a totipotent state during preimplantation development. However, the …

The first major developmental transition in vertebrate embryos is the maternal-to-zygotic
transition (MZT) when maternal mRNAs are degraded and zygotic transcription begins …

Organization of the genome into euchromatin and heterochromatin appears to be
evolutionarily conserved and relatively stable during lineage differentiation. In an effort to …

Polycomb group proteins and the related histone modification H3K27me3 can maintain the
silencing of key developmental regulators and provide cellular memory. However, how such …

Drastic epigenetic reprogramming takes place during preimplantation development, leading
to the conversion of terminally differentiated gametes to a totipotent embryo. Deficiencies in …