Amide proton transfer‐weighted (APTw) MR imaging shows promise as a biomarker of brain
tumor status. Currently used APTw MRI pulse sequences and protocols vary substantially …

Activated choline metabolism is a hallmark of carcinogenesis and tumor progression, which
leads to elevated levels of phosphocholine and glycerophosphocholine in all types of …

Magnetic resonance (MR) is a powerful technique for noninvasively probing molecular
species in vivo but suffers from low signal sensitivity. Saturation transfer (ST) MRI …

Currently, human magnetic resonance (MR) examinations are becoming highly specialized
with a pre-defined and often relatively small target in the body. Conventionally, clinical MR …

Purpose Nuclear Overhauser enhancemen mediated saturation transfer effect, termed NOE
(− 3.5 ppm), is a major source of CEST MRI contrasts at 3.5 ppm in the brain. Previous …

Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) has
emerged as a novel means for sensitive detection of dilute labile protons and chemical …

Chemical exchange saturation transfer (CEST) MRI has gained recognition as a valuable
addition to the molecular imaging and quantitative biomarker arsenal, especially for …

Background Amide proton transfer (APT) imaging has been increasingly applied in tumor
characterization. However, its value in evaluating breast cancer remains undetermined …

Chemical exchange saturation transfer (CEST) MRI is a promising molecular imaging tool
which allows the specific detection of metabolites that contain exchangeable amide, amine …

Purpose The application of amide proton transfer (APT) CEST MRI for diagnosis of breast
cancer is of emerging interest. However, APT imaging in the human breast is affected by the …