Blood platelets in infection: the multiple roles of the platelet signalling machinery

SMG Trivigno, GF Guidetti, SS Barbieri… - International Journal of …, 2023 - mdpi.com
Platelets are classically recognized for their important role in hemostasis and thrombosis but
they are also involved in many other physiological and pathophysiological processes …

Orthohantavirus pathogenesis and cell tropism

D Noack, M Goeijenbier, CBEM Reusken… - Frontiers in cellular …, 2020 - frontiersin.org
Orthohantaviruses are zoonotic viruses that are naturally maintained by persistent infection
in specific reservoir species. Although these viruses mainly circulate among rodents …

[HTML][HTML] Biomechanical characterization of SARS-CoV-2 spike RBD and human ACE2 protein-protein interaction

W Cao, C Dong, S Kim, D Hou, W Tai, L Du, W Im… - Biophysical journal, 2021 - cell.com
The current COVID-19 pandemic has led to a devastating impact across the world. Severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2)(the virus causing COVID-19) is …

Integrin activation is an essential component of SARS-CoV-2 infection

P Simons, DA Rinaldi, V Bondu, AM Kell, S Bradfute… - Scientific Reports, 2021 - nature.com
SARS-CoV-2 infection depends on binding its spike (S) protein to angiotensin-converting
enzyme 2 (ACE2). The S protein expresses an RGD motif, suggesting that integrins may be …

Beyond the matrix: the many non-ECM ligands for integrins

B LaFoya, JA Munroe, A Miyamoto… - International journal of …, 2018 - mdpi.com
The traditional view of integrins portrays these highly conserved cell surface receptors as
mediators of cellular attachment to the extracellular matrix (ECM), and to a lesser degree, as …

Biomimetic Hydrogels in the Study of Cancer Mechanobiology: Overview, Biomedical Applications, and Future Perspectives

AZ Sahan, M Baday, CB Patel - Gels, 2022 - mdpi.com
Hydrogels are biocompatible polymers that are tunable to the system under study, allowing
them to be widely used in medicine, bioprinting, tissue engineering, and biomechanics …

Therapeutic potential for P2Y2 receptor antagonism

KJ Jasmer, K Muñoz Forti, LT Woods, S Cha… - Purinergic …, 2023 - Springer
G protein-coupled receptors are the target of more than 30% of all FDA-approved drug
therapies. Though the purinergic P2 receptors have been an attractive target for therapeutic …

Calcium-mediated biophysical binding of Cryptosporidium parvum oocysts to surfaces is sensitive to oocyst age

T Sarkhosh, XF Zhang, KL Jellison… - Applied and …, 2019 - Am Soc Microbiol
Cryptosporidium parvum causes potentially life-threatening gastrointestinal disease in
humans and may not be effectively removed from drinking water via conventional methods …

Upregulation of P2Y2R, Active uPA, and PAI-1 Are Essential Components of Hantavirus Cardiopulmonary Syndrome

V Bondu, C Bitting, VL Poland, JA Hanson… - Frontiers in cellular …, 2018 - frontiersin.org
Sin Nombre virus (SNV) causes hantavirus cardiopulmonary pulmonary syndrome (HCPS)
with the loss of pulmonary vascular endothelial integrity, and pulmonary edema without …

A high-throughput flow cytometry screen identifies molecules that inhibit hantavirus cell entry

T Buranda, C Gineste, Y Wu, V Bondu… - … Life Sciences R&D, 2018 - journals.sagepub.com
Hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) and hantavirus
cardiopulmonary syndrome (HCPS), which infects more than 200,000 people worldwide. Sin …