The tumor microenvironment (TME) plays an important role in neoplastic development.
Matrix metalloproteinases (MMPs) are critically involved in tumorigenesis by modulation of …

Drug resistance is one of the biggest challenges in cancer treatment and limits the potential
to cure patients. In many tumors, sustained activation of the protein NRF2 makes tumor cells …

The transcription coactivator YAP plays a vital role in Hippo pathway for organ-size control
and tissue homeostasis. Recent studies have demonstrated YAP is closely related to …

The TFE3 and MITF master transcription factors maintain metabolic homeostasis by
regulating lysosomal, melanocytic, and autophagy genes. Previous studies posited that their …

Cancer immunotherapies, including immune checkpoint inhibitors and immune pathway–
targeted therapies, are promising clinical strategies for treating cancer. However, drug …

The F-box protein beta-transducin repeat containing protein (β-TrCP) acts as a substrate
adapter for the SCF E3 ubiquitin ligase complex, plays a crucial role in cell physiology, and …

YAP/TAZ transcriptional co‐activators play pivotal roles in tumorigenesis. In the Hippo
pathway, diverse signals activate the MST‐LATS kinase cascade that leads to YAP/TAZ …

Ubiquitin-dependent proteolysis regulates diverse cellular functions with high substrate
specificity, which hinges on the ability of ubiquitin E3 ligases to decode the targets' …

Retinoblastoma (RB) protein can exert tumor suppressor functions even when it becomes
phosphorylated. It is thus essential to understand how phosphorylated RB (p-RB) …

Colorectal cancer (CRC) is one of the leading causes of mortality for cancer in industrialized
countries. The link between diet and CRC is well-known, and presumably CRC is the type of …