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Paradoxical roles of antioxidant enzymes: basic mechanisms and health implications
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from
aerobic metabolism, as a result of accidental electron leakage as well as regulated …
aerobic metabolism, as a result of accidental electron leakage as well as regulated …
Thioredoxins, glutaredoxins, and peroxiredoxins—molecular mechanisms and health significance: from cofactors to antioxidants to redox signaling
EM Hanschmann, JR Godoy, C Berndt… - Antioxidants & redox …, 2013 - liebertpub.com
Abstract Thioredoxins (Trxs), glutaredoxins (Grxs), and peroxiredoxins (Prxs) have been
characterized as electron donors, guards of the intracellular redox state, and “antioxidants” …
characterized as electron donors, guards of the intracellular redox state, and “antioxidants” …
Sulforaphane reactivates cellular antioxidant defense by inducing Nrf2/ARE/Prdx6 activity during aging and oxidative stress
E Kubo, B Chhunchha, P Singh, H Sasaki, DP Singh - Scientific reports, 2017 - nature.com
Upon oxidative stress and aging, Nrf2 (NFE2-related factor2) triggers antioxidant defense
genes to defends against homeostatic failure. Using human (h) or rat (r) lens epithelial cells …
genes to defends against homeostatic failure. Using human (h) or rat (r) lens epithelial cells …
The role of peroxiredoxins in cancer
A Nicolussi, S D'inzeo, C Capalbo… - Molecular and …, 2017 - spandidos-publications.com
Peroxiredoxins (PRDXs) are a ubiquitously expressed family of small (22–27 kDa) non-
seleno peroxidases that catalyze the peroxide reduction of H2O2, organic hydroperoxides …
seleno peroxidases that catalyze the peroxide reduction of H2O2, organic hydroperoxides …
The vitamin nicotinamide: translating nutrition into clinical care
K Maiese, ZZ Chong, J Hou, YC Shang - Molecules, 2009 - mdpi.com
Nicotinamide, the amide form of vitamin B3 (niacin), is changed to its mononucleotide
compound with the enzyme nicotinic acide/nicotinamide adenylyl-transferase, and …
compound with the enzyme nicotinic acide/nicotinamide adenylyl-transferase, and …
[HTML][HTML] The phospholipase A2 activity of peroxiredoxin 6 [S]
AB Fisher - Journal of Lipid Research, 2018 - Elsevier
Peroxiredoxin 6 (Prdx6) is a Ca 2+-independent intracellular phospholipase A 2 (called
aiPLA 2) that is localized to cytosol, lysosomes, and lysosomal-related organelles. Activity is …
aiPLA 2) that is localized to cytosol, lysosomes, and lysosomal-related organelles. Activity is …
Hallmarks of lens aging and cataractogenesis
TFL Wishart, M Flokis, DY Shu, SJ Das… - Experimental Eye …, 2021 - Elsevier
Lens homeostasis and transparency are dependent on the function and intercellular
communication of its epithelia. While the lens epithelium is uniquely equipped with …
communication of its epithelia. While the lens epithelium is uniquely equipped with …
[HTML][HTML] Clock protein Bmal1 and Nrf2 cooperatively control aging or oxidative response and redox homeostasis by regulating rhythmic expression of Prdx6
B Chhunchha, E Kubo, DP Singh - Cells, 2020 - mdpi.com
Many disorders of aging, including blinding-diseases, are associated with deficiency of brain
and muscle arnt-like protein 1 (Bmal1) and, thereby, dysregulation of antioxidant-defense …
and muscle arnt-like protein 1 (Bmal1) and, thereby, dysregulation of antioxidant-defense …
[HTML][HTML] Roles of TGF β and FGF signals in the lens: tropomyosin regulation for posterior capsule opacity
E Kubo, T Shibata, DP Singh, H Sasaki - International journal of molecular …, 2018 - mdpi.com
Transforming growth factor (TGF) β and fibroblast growth factor (FGF) 2 are related to the
development of posterior capsule opacification (PCO) after lens extraction surgery and other …
development of posterior capsule opacification (PCO) after lens extraction surgery and other …
Emerging issues in radiogenic cataracts and cardiovascular disease
N Hamada, Y Fujimichi, T Iwasaki, N Fujii… - Journal of radiation …, 2014 - academic.oup.com
Abstract In 2011, the International Commission on Radiological Protection issued a
statement on tissue reactions (formerly termed non-stochastic or deterministic effects) to …
statement on tissue reactions (formerly termed non-stochastic or deterministic effects) to …