The mitogen-activated protein (MAP) kinase family members, which include the extracellular
response kinases (ERK), p38, and c-Jun amino terminal kinases (JNK), play a role in …

Publisher Summary This chapter discusses that the network of immune and inflammatory
responses is comprised of a variety of cell types. Coordination of this network occurs through …

Signal transduction via MAP kinase pathways plays a key role in a variety of cellular
responses, including growth factor‐induced proliferation, differentiation and cell death. In …

Early inflammatory events include cytokine release, activation, and rapid accumulation of
neutrophils, with subsequent recruitment of mononuclear cells. The p38 mitogen-activated …

Objective To evaluate the effects of SB 242235, a potent and selective inhibitor of p38
mitogen‐activated protein (MAP) kinase, on joint integrity in rats with adjuvant‐induced …

JAK-3 has been shown to play a key role in cytokine signaling via γc, eg IL-2, 4, 7, 9, 15, 21.
The current study describes the immunosuppressive effects of CP-690550, a novel, small …

The c‐Jun aminoterminal kinase (JNK) and p38 mitogen‐activated protein (MAP) kinase
signaling pathways have been associated with cell death, differentiation and proliferation …

The p38 mitogen-activated protein kinase (MAPK) signaling pathway regulates a wide range
of inflammatory responses in many different cells. Inhibition of p38 MAPK before exposing a …

Alleviation of pain and inhibition of inflammation are the primary goals of pharmacotherapy
of osteoarthritis (OA). These therapeutic goals can almost always be accomplished by the …

YM-58483/BTP2 is a blocker of store-operated Ca2+ entry (SOCE), which regulates the
activation of non-excitable cells such as lymphocytes. YM-58483 has been reported to …