Pharmacology, physiology, and mechanisms of action of dipeptidyl peptidase-4 inhibitors
Abstract Dipeptidyl peptidase-4 (DPP4) is a widely expressed enzyme transducing actions
through an anchored transmembrane molecule and a soluble circulating protein. Both …
through an anchored transmembrane molecule and a soluble circulating protein. Both …
Glucagon receptor signaling and glucagon resistance
L Janah, S Kjeldsen, KD Galsgaard… - International journal of …, 2019 - mdpi.com
Hundred years after the discovery of glucagon, its biology remains enigmatic. Accurate
measurement of glucagon has been essential for uncovering its pathological hypersecretion …
measurement of glucagon has been essential for uncovering its pathological hypersecretion …
Islet α cells and glucagon—critical regulators of energy homeostasis
Glucagon is secreted from islet α cells and controls blood levels of glucose in the fasting
state. Impaired glucagon secretion predisposes some patients with type 1 diabetes mellitus …
state. Impaired glucagon secretion predisposes some patients with type 1 diabetes mellitus …
Glucagon and amino acids are linked in a mutual feedback cycle: the liver–α-cell axis
Glucagon is usually viewed as an important counterregulatory hormone in glucose
metabolism, with actions opposing those of insulin. Evidence exists that shows glucagon is …
metabolism, with actions opposing those of insulin. Evidence exists that shows glucagon is …
Glucose‐responsive composite microneedle patch for hypoglycemia‐triggered delivery of native glucagon
Insulin‐dependent patients with diabetes mellitus require multiple daily injections of
exogenous insulin to combat hyperglycemia. However, administration of excess insulin can …
exogenous insulin to combat hyperglycemia. However, administration of excess insulin can …
Evidence of extrapancreatic glucagon secretion in man
Glucagon is believed to be a pancreas-specific hormone, and hyperglucagonemia has been
shown to contribute significantly to the hyperglycemic state of patients with diabetes. This …
shown to contribute significantly to the hyperglycemic state of patients with diabetes. This …
Hyperglucagonaemia analysed by glucagon sandwich ELISA: nonspecific interference or truly elevated levels?
Aim/hypothesis Hyperglucagonaemia is a characteristic of several clinical conditions (eg
end-stage renal disease (ESRD), type 2 diabetes, obesity before and after Roux-en-Y …
end-stage renal disease (ESRD), type 2 diabetes, obesity before and after Roux-en-Y …
The biology of glucagon and the consequences of hyperglucagonemia
The proglucagon-derived peptide hormone, glucagon, comprises 29 amino acids. Its
secretion from the pancreatic α cells is regulated by several factors. Glucagon increases …
secretion from the pancreatic α cells is regulated by several factors. Glucagon increases …
[HTML][HTML] SGLT1 in pancreatic α cells regulates glucagon secretion in mice, possibly explaining the distinct effects of SGLT2 inhibitors on plasma glucagon levels
T Suga, O Kikuchi, M Kobayashi, S Matsui… - Molecular …, 2019 - Elsevier
Objectives It is controversial whether sodium glucose transporter (SGLT) 2 inhibitors
increase glucagon secretion via direct inhibition of SGLT2 in pancreatic α cells. The role of …
increase glucagon secretion via direct inhibition of SGLT2 in pancreatic α cells. The role of …
Panorama of mediators in postpancreatitis diabetes mellitus
Growing evidence compels a reconsideration of the dogma that mechanical β-cell
destruction (and the resulting insulin deficiency) is the only underlying mechanism of …
destruction (and the resulting insulin deficiency) is the only underlying mechanism of …