Regulation of placental development and its impact on fetal growth—new insights from mouse models
The placenta is the chief regulator of nutrient supply to the growing embryo during gestation.
As such, adequate placental function is instrumental for developmental progression …
As such, adequate placental function is instrumental for developmental progression …
The TGF-β family in the reproductive tract
The transforming growth factor β (TGF-β) family has a profound impact on the reproductive
function of various organisms. In this review, we discuss how highly conserved members of …
function of various organisms. In this review, we discuss how highly conserved members of …
TGFβ superfamily signaling and uterine decidualization
N Ni, Q Li - Reproductive biology and endocrinology, 2017 - Springer
Decidualization is an intricate biological process where extensive morphological, functional,
and genetic changes take place in endometrial stromal cells to support the development of …
and genetic changes take place in endometrial stromal cells to support the development of …
Muscle-derived myostatin is a major endocrine driver of follicle-stimulating hormone synthesis
L Ongaro, X Zhou, Y Wang, H Schultz, Z Zhou… - Science, 2025 - science.org
Myostatin is a paracrine myokine that regulates muscle mass in a variety of species,
including humans. In this work, we report a functional role for myostatin as an endocrine …
including humans. In this work, we report a functional role for myostatin as an endocrine …
A GREB1-steroid receptor feedforward mechanism governs differential GREB1 action in endometrial function and endometriosis
Cellular responses to the steroid hormones, estrogen (E2), and progesterone (P4) are
governed by their cognate receptor's transcriptional output. However, the feed-forward …
governed by their cognate receptor's transcriptional output. However, the feed-forward …
Heterogeneous cardiac-derived and neural crest–derived aortic smooth muscle cells exhibit similar transcriptional changes after TGFβ signaling disruption
BACKGROUND: Smooth muscle cells (SMCs) of cardiac and neural crest origin contribute to
the develo** proximal aorta and are linked to disease propensity in adults. METHODS …
the develo** proximal aorta and are linked to disease propensity in adults. METHODS …
Uterine double-conditional inactivation of Smad2 and Smad3 in mice causes endometrial dysregulation, infertility, and uterine cancer
M Kriseman, D Monsivais, J Agno… - Proceedings of the …, 2019 - National Acad Sciences
SMAD2 and SMAD3 are downstream proteins in the transforming growth factor-β (TGF β)
signaling pathway that translocate signals from the cell membrane to the nucleus, bind DNA …
signaling pathway that translocate signals from the cell membrane to the nucleus, bind DNA …
[HTML][HTML] Evidence for shared molecular pathways of dysregulated decidualization in preeclampsia and endometrial disorders revealed by microarray data integration
MB Rabaglino, KP Conrad - The FASEB Journal, 2019 - ncbi.nlm.nih.gov
Microarray data of chorionic villous samples (CVSs) obtained from women of∼ 11.5
gestational weeks who developed preeclampsia with severe features (sPE; PE-CVS) …
gestational weeks who developed preeclampsia with severe features (sPE; PE-CVS) …
Uterine-specific Ezh2 deletion enhances stromal cell senescence and impairs placentation, resulting in pregnancy loss
VK Sirohi, TI Medrano, A Kannan, IC Bagchi, PS Cooke - Iscience, 2023 - cell.com
Maternal uterine remodeling facilitates embryo implantation, stromal cell decidualization and
placentation, and perturbation of these processes may cause pregnancy loss. Enhancer of …
placentation, and perturbation of these processes may cause pregnancy loss. Enhancer of …
BMP7 induces uterine receptivity and blastocyst attachment
In women, the window of implantation is limited to a brief 2-to 3-day period characterized by
optimal levels of circulating ovarian hormones and a receptive endometrium. Although the …
optimal levels of circulating ovarian hormones and a receptive endometrium. Although the …