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Emerging roles of allosteric modulators in the regulation of protein‐protein interactions (PPIs): A new paradigm for PPI drug discovery
Protein‐protein interactions (PPIs) are closely implicated in various types of cellular activities
and are thus pivotal to health and disease states. Given their fundamental roles in a wide …
and are thus pivotal to health and disease states. Given their fundamental roles in a wide …
Exploring the protein–protein interaction landscape in plants
S Struk, A Jacobs… - Plant, cell & …, 2019 - Wiley Online Library
Protein–protein interactions (PPIs) represent an essential aspect of plant systems biology.
Identification of key protein players and their interaction networks provide crucial insights …
Identification of key protein players and their interaction networks provide crucial insights …
A plant genetic network for preventing dysbiosis in the phyllosphere
The aboveground parts of terrestrial plants, collectively called the phyllosphere, have a key
role in the global balance of atmospheric carbon dioxide and oxygen. The phyllosphere …
role in the global balance of atmospheric carbon dioxide and oxygen. The phyllosphere …
A circadian clock output functions independently of phyB to sustain daytime PIF3 degradation
The circadian clock is an endogenous oscillator, and its importance lies in its ability to impart
rhythmicity on downstream biological processes, or outputs. Our knowledge of output …
rhythmicity on downstream biological processes, or outputs. Our knowledge of output …
Targeting protein-protein interactions with low molecular weight and short peptide modulators: insights on disease pathways and starting points for drug discovery
ABSTRACT Introduction Protein-protein interactions (PPIs) have been often considered
undruggable targets although they are attractive for the discovery of new therapeutics. The …
undruggable targets although they are attractive for the discovery of new therapeutics. The …
GIGANTEA recruits the UBP12 and UBP13 deubiquitylases to regulate accumulation of the ZTL photoreceptor complex
ZEITLUPE (ZTL), a photoreceptor with E3 ubiquitin ligase activity, communicates end-of-day
light conditions to the plant circadian clock. It still remains unclear how ZTL protein …
light conditions to the plant circadian clock. It still remains unclear how ZTL protein …
Plasmodesmata-dependent intercellular movement of bacterial effectors
Pathogenic microorganisms deliver protein effectors into host cells to suppress host immune
responses. Recent findings reveal that phytopathogens manipulate the function of plant cell …
responses. Recent findings reveal that phytopathogens manipulate the function of plant cell …
Arabidopsis Tubby domain‐containing F‐box proteins positively regulate immunity by modulating PI4Kβ protein levels
The Tubby domain, named after the TUBBY protein in mice, binds to phosphatidylinositol 4,
5‐bisphosphate. Arabidopsis has 11 Tubby domain‐containing proteins referred to as …
5‐bisphosphate. Arabidopsis has 11 Tubby domain‐containing proteins referred to as …
Approaches to identify and characterize microProteins and their potential uses in biotechnology
MicroProteins are small proteins that contain a single protein domain and are related to
larger, often multi-domain proteins. At the molecular level, microProteins act by interfering …
larger, often multi-domain proteins. At the molecular level, microProteins act by interfering …
[HTML][HTML] Predicting functions of uncharacterized human proteins: from canonical to proteoforms
E Poverennaya, O Kiseleva, A Romanova… - Genes, 2020 - mdpi.com
Despite tremendous efforts in genomics, transcriptomics, and proteomics communities, there
is still no comprehensive data about the exact number of protein-coding genes, translated …
is still no comprehensive data about the exact number of protein-coding genes, translated …