Receptor tyrosine kinase signalling pathways have been successfully targeted to inhibit
proliferation and angiogenesis for cancer therapy. However, kinase deregulation has been …

Despite advances in genetic and proteomic techniques, a complete portrait of the proteome
and its complement of dynamic interactions and modifications remains a lofty, and as of yet …

Covering: 2010 up to 2016 Deconvoluting the mode of action of natural products and drugs
remains one of the biggest challenges in chemistry and biology today. Chemical proteomics …

Natural products are an important source of new drugs for the treatment of various diseases.
However, develo** natural product-based new medicines through random moiety …

Activity-based protein profiling (ABPP) has become an emerging chemical proteomic
approach to illustrate the interaction mechanisms between compounds and proteins. This …

Activity-based protein profiling (ABPP) is recognized as a powerful and versatile
chemoproteomic technology in drug discovery. Central to ABPP is the use of activity-based …

Covalent drugs have experienced significant renewed interest in drug discovery. This
resurgence has been accompanied by a better understanding of the reactivity relationships …

Kinome-wide profiling platforms have comprehensively identified the relevant kinases that
are targeted by numerous protein kinase inhibitors. However, recent projects have begun to …

Neutrophils, the front line defenders against infection, express four serine proteases (NSPs)
that play roles in the control of cell-signaling pathways and defense against pathogens and …

Polysorbate is widely used to maintain stability of biotherapeutic proteins in pharmaceutical
formulation development. Degradation of polysorbate can lead to particle formation in drug …