Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …

Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

One of the most striking adaptations to exercise is the skeletal muscle hypertrophy that
occurs in response to resistance exercise. A large body of work shows that a mammalian …

Satellite cells support adult skeletal muscle fiber adaptations to loading in numerous ways.
The fusion of satellite cells, driven by cell‐autonomous and/or extrinsic factors, contributes …

The ribosome is the enzymatic macromolecular machine responsible for protein synthesis.
The rates of protein synthesis are primarily dependent on translational efficiency and …

The peculiar ability of skeletal muscle tissue to operate adaptive changes during post-natal
development and adulthood has been associated with the existence of adult somatic stem …

The α7β1-integrin is a transmembrane adhesion protein that connects laminin in the
extracellular matrix (ECM) with actin in skeletal muscle fibers. The α7β1-integrin is highly …

Recent loss-of-function studies show that satellite cell depletion does not promote
sarcopenia or unloading-induced atrophy, and does not prevent regrowth. Although …

Skeletal muscle plays a pivotal role in the maintenance of physical and metabolic health
and, critically, mobility. Accordingly, strategies focused on increasing the quality and quantity …

Cellular senescence is a state of cell cycle arrest induced by several forms of metabolic
stress. Senescent cells accumulate with advancing age and have a distinctive phenotype …