This review describes off-resonance R 1ρ relaxation dispersion NMR methods for
characterizing microsecond-to-millisecond chemical exchange in uniformly 13 C/15 N …

Transcription factors recognize specific genomic sequences to regulate complex gene-
expression programs. Although it is well-established that transcription factors bind to specific …

DNA (2′-deoxyribonucleic acid) and RNA (ribonucleic acid) play diverse functional roles in
biology and disease. Despite being comprised primarily of only four cognate nucleobases …

Biomolecules form dynamic ensembles of many inter-converting conformations which are
key for understanding how they fold and function. However, determining ensembles is …

High-order quantum chemistry is applied to hydrogen-bonded natural DNA nucleobase
pairs [adenine: thymine (A: T) and guanine: cytosine (G: C)] and non-natural Hachimoji …

ABSTRACT N 6-methyladenosine (m6A) is a post-transcriptional modification that controls
gene expression by recruiting proteins to RNA sites. The modification also slows …

The majority of base pairs in double-stranded DNA exist in the canonical Watson-Crick
geometry. However, they can also adopt alternate Hoogsteen conformations in various …

Atomic mutagenesis is the key to advance our understanding of RNA recognition and RNA
catalysis. To this end, deazanucleosides are utilized to evaluate the participation of specific …

NMR off-resonance R 1ρ relaxation dispersion measurements on base carbon and nitrogen
nuclei have revealed that wobble G· T/U mismatches in DNA and RNA duplexes exist in …

Fourier transform infrared (FTIR) spectroscopy has been widely used for the analysis of both
protein and nucleic acid secondary structure. This is one of the vibration spectroscopy …