The search for inhibitors of macrodomains for targeting the readers and erasers of mono-ADP-ribosylation
W Fu, H Yao, M Buetepage, Q Zhao, B Luescher… - Drug Discovery …, 2021 - Elsevier
Macrodomains are evolutionarily conserved structural elements. Many macrodomains
feature as binding modules of ADP-ribose, thus participating in the recognition and removal …
feature as binding modules of ADP-ribose, thus participating in the recognition and removal …
Alphaviruses: Host pathogenesis, immune response, and vaccine & treatment updates
I Guerrero-Arguero… - Journal of General …, 2021 - microbiologyresearch.org
Human pathogens belonging to the Alphavirus genus, in the Togaviridae family, are
transmitted primarily by mosquitoes. The signs and symptoms associated with these viruses …
transmitted primarily by mosquitoes. The signs and symptoms associated with these viruses …
Withaferin A inhibits Chikungunya virus nsP2 protease and shows antiviral activity in the cell culture and mouse model of virus infection
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus causing fever, myalgia,
and debilitating joint swelling and pain, which in many patients becomes chronic. The …
and debilitating joint swelling and pain, which in many patients becomes chronic. The …
Synthesis and Anti-Chikungunya Virus (CHIKV) Activity of Novel 1, 4-Naphthoquinone Sulfonamide and Sulfonate Ester Derivatives
PAF Pacheco, DT Gonzaga… - Journal of the Brazilian …, 2022 - SciELO Brasil
Chikungunya virus (CHIKV) is a re-emerging disease caused by an alphavirus of the
Togaviridae family. Since its first description in 1952, the disease has spread worldwide …
Togaviridae family. Since its first description in 1952, the disease has spread worldwide …
In Silico Drug Repurposing Uncovered the Antiviral Potential of the Antiparasitic Drug Oxibendazole Against the Chikungunya Virus
VW Rabelo, ML Sanchez-Nuñez… - ACS …, 2024 - ACS Publications
Chikungunya virus (CHIKV) has been reported in over 120 countries and is the causative
agent of Chikungunya fever. The debilitating nature of this disease, which can persist …
agent of Chikungunya fever. The debilitating nature of this disease, which can persist …
Structural insights into the inhibition of the nsP2 protease from Chikungunya virus by molecular modeling approaches
VWH Rabelo, ICN de Palmer Paixão… - Journal of Molecular …, 2022 - Springer
Chikungunya virus (CHIKV) is the etiological agent of the Chikungunya fever which has
spread worldwide. Clinically, this disease may lead to prolonged incapacitating joint pain …
spread worldwide. Clinically, this disease may lead to prolonged incapacitating joint pain …
Infectomics of Chikungunya Virus: Roles Played by Host Factors
NAAB Adnan, N Kalam, GLZ Jiunn… - … journal of tropical …, 2024 - pubmed.ncbi.nlm.nih.gov
Chikungunya virus (CHIKV), prevalent in tropical regions, is known for causing frequent
outbreaks, particularly in Central Africa, South America, and Southeast Asia. It is an …
outbreaks, particularly in Central Africa, South America, and Southeast Asia. It is an …
Deciphering the human cellular interactors of alphavirus unique domain of chikungunya virus
R Ghildiyal, R Gabrani - Virus Research, 2021 - Elsevier
The life-threatening re-emerged chikungunya virus (CHIKV) can cause an epidemic
outbreak and still has no vaccine available so far. Alphavirus unique domain (AUD) of …
outbreak and still has no vaccine available so far. Alphavirus unique domain (AUD) of …